{"id":"W3111753833","doi":"10.1093/neuonc/noaa222.088","title":"DIPG-41. DISSECTING THE MECHANISTIC BASIS FOR <i>ACVR1</i> AND <i>PIK3CA</i> MUTATION CO-OCCURRENCE IN DIFFUSE MIDLINE GLIOMAS USING GENETICALLY ENGINEERED MOUSE MODELS","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"OLIG2; Biology; Forebrain; Gene; Carcinogenesis; Epigenetics; Transcription factor; Cancer research; Histone; Transcriptome; Mutation; Oligodendrocyte; Genetics; Neuroscience; Gene expression; Myelin; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003000466,0.0006433434,0.0003291185,0.0006684379,0.0003498162,0.0006150936,0.0007246041,0.000974976,0.005596996],"category_scores_gemma":[0.0001314299,0.0003570004,0.0005593962,0.000294039,0.0006763319,0.000461052,0.00049554,0.001896618,0.001664629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008709664,"about_ca_system_score_gemma":0.0004999902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001636257,"about_ca_topic_score_gemma":0.002555975,"domain_scores_codex":[0.9995958,0.00005889526,0.00003082895,0.0001058954,0.00009641129,0.0001121178],"domain_scores_gemma":[0.9997846,0.00002294402,0.00005679881,0.00002161212,0.00001386726,0.0001001212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003139769,0.00009207614,0.0003519221,0.00009326772,0.00001456407,0.0002378123,0.00001887647,0.0001651273,0.9953527,0.001159137,0.0003333754,0.001867],"study_design_scores_gemma":[0.0002212726,0.0008476689,0.006472699,0.00004155515,0.0000601801,0.001383842,0.0001247269,0.003586261,0.9696739,0.000452606,0.01711278,0.00002245965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530519,0.002708269,0.01632784,0.001921236,0.0003248416,0.0004068916,0.008753012,0.001107344,0.01539876],"genre_scores_gemma":[0.9762314,0.001021178,0.006214073,0.0005531406,0.00002235177,0.0003732269,0.00331545,0.0002010821,0.01206809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005596996,"threshold_uncertainty_score":0.01872379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0500216919919357,"score_gpt":0.3121620055092161,"score_spread":0.2621403135172804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}