{"id":"W3111776013","doi":"10.1002/alz.12252","title":"Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University; Montreal Neurological Institute and Hospital; University of Toronto; Occupational Cancer Research Centre; Health Sciences Centre; McGill University Health Centre; Sunnybrook Health Science Centre; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; British Academy; Cambridge Trust; Wellcome Trust; Alzheimer's Society; UK Dementia Research Institute; Ministero della Salute; Canadian Institutes of Health Research; Guarantors of Brain; Astex Pharmaceuticals; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Medical Research Council; Biogen; Eli Lilly and Company","keywords":"Apathy; Frontotemporal dementia; Subclinical infection; Dementia; Psychology; C9orf72; Cognitive decline; Cognition; Atrophy; Medicine; Psychiatry; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004661983,0.0005265451,0.000367763,0.000806112,0.0005235446,0.0005667477,0.0003184173,0.0005859361,0.001932151],"category_scores_gemma":[0.002238016,0.0002231724,0.0003354649,0.0006026806,0.0003474801,0.0004352823,0.0004172122,0.0005311007,0.0002799349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004072215,"about_ca_system_score_gemma":0.000284776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004840935,"about_ca_topic_score_gemma":0.007642351,"domain_scores_codex":[0.9998381,0.00003526228,0.00002180713,0.00003673171,0.00004123372,0.00002680352],"domain_scores_gemma":[0.9988243,0.0001745248,0.0006611663,0.00006994315,0.00008395891,0.0001861119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003013283,0.00006643546,0.9969552,0.00001068893,0.00003590318,0.0002236862,0.00007248493,0.000060726,0.0004693746,0.000009570351,0.00005936841,0.001735192],"study_design_scores_gemma":[0.000007601946,0.00009452843,0.9988117,0.000004690932,0.00001508098,0.0006246407,0.00005066985,0.0002340471,0.00006485942,0.00006239735,0.00002711926,0.000002622486],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996998,0.00005405178,0.00002000807,0.00001380984,0.000001307854,0.000002228274,0.0000622077,0.000002081493,0.0001444602],"genre_scores_gemma":[0.9997345,0.00002718206,0.00004694951,0.000005199238,0.000002904276,0.000001915387,0.0001080598,5.387758e-7,0.00007276448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004840935,"threshold_uncertainty_score":0.009625554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03252640559771545,"score_gpt":0.2942889333306602,"score_spread":0.2617625277329447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}