{"id":"W3111776013","doi":"10.1002/alz.12252","title":"Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University; Montreal Neurological Institute and Hospital; University of Toronto; Occupational Cancer Research Centre; Health Sciences Centre; McGill University Health Centre; Sunnybrook Health Science Centre; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; British Academy; Cambridge Trust; Wellcome Trust; Alzheimer's Society; UK Dementia Research Institute; Ministero della Salute; Canadian Institutes of Health Research; Guarantors of Brain; Astex Pharmaceuticals; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Medical Research Council; Biogen; Eli Lilly and Company","keywords":"Apathy; Frontotemporal dementia; Subclinical infection; Dementia; Psychology; C9orf72; Cognitive decline; Cognition; Atrophy; Medicine; Psychiatry; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001402486,0.0003034715,0.0004421348,0.00009051638,0.00008915508,0.00006696457,0.0001926856,0.0001368064,0.000859911],"category_scores_gemma":[0.00008183607,0.0002688614,0.00006214115,0.0002300406,0.000174371,0.0001588223,0.0003727351,0.0002819643,0.00005210585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001165919,"about_ca_system_score_gemma":0.00006321731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002562997,"about_ca_topic_score_gemma":0.0001328453,"domain_scores_codex":[0.9976209,0.0001504036,0.0004433489,0.0006086846,0.0006061462,0.0005705534],"domain_scores_gemma":[0.9990578,0.0000776457,0.0001253325,0.0002026173,0.00008750937,0.0004491261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003317421,0.00008749012,0.9242324,0.0000675851,0.007417113,0.00008000729,0.002704495,0.000002373799,0.01248898,0.000003043191,0.009021556,0.04356316],"study_design_scores_gemma":[0.00437618,0.0007627945,0.9766566,0.0001198121,0.004641345,0.00001358843,0.000104151,0.009117097,0.003046902,0.00009074435,0.000773883,0.0002969737],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9222826,0.06162691,0.0001049208,0.01453932,0.00006125521,0.001154722,0.00008413999,0.0000666669,0.00007948638],"genre_scores_gemma":[0.991605,0.0002680335,0.001632079,0.005983207,0.0002062887,0.00008735224,0.0001561297,0.00005139977,0.00001054729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06932239,"threshold_uncertainty_score":0.9999763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03252640559771545,"score_gpt":0.2942889333306602,"score_spread":0.2617625277329447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}