{"id":"W3111791445","doi":"10.3390/bioengineering7040164","title":"Toward Spatial Identities in Human Brain Organoids-on-Chip Induced by Morphogen-Soaked Beads","year":2020,"lang":"en","type":"article","venue":"Bioengineering","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Ministry of Science and Technology of the People's Republic of China; Israel Science Foundation; National Natural Science Foundation of China; International Development Research Centre; National Science Foundation; Yale University; Impact Fund; United States-Israel Binational Science Foundation","keywords":"Morphogen; Organoid; Wnt signaling pathway; Biology; Cell biology; Embryonic stem cell; Developmental biology; Neuroscience; Anatomy; Gene; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112709,0.0001902144,0.000165564,0.00007963618,0.00003941431,0.00004247037,0.0002900787,0.000150059,0.00004529366],"category_scores_gemma":[0.0001086306,0.0002096845,0.00006159522,0.0001608866,0.00002695882,0.000005398004,0.0001681427,0.000187785,0.00003512941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000443557,"about_ca_system_score_gemma":0.00003189208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009251718,"about_ca_topic_score_gemma":0.00001621015,"domain_scores_codex":[0.9988031,0.00003603437,0.0002116991,0.0003710117,0.000219389,0.0003587148],"domain_scores_gemma":[0.9995794,0.00001124487,0.00002955662,0.000205915,0.00002517842,0.0001487292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002593599,0.00002425107,0.0004653243,0.00004509478,0.00002381291,0.00001914403,0.00007476634,0.0003092965,0.9965768,0.00003416723,0.002180745,0.0002206665],"study_design_scores_gemma":[0.000697128,0.0003297523,0.00130756,0.00002029333,0.000003308069,0.000003607381,0.00004920913,0.0008274651,0.9921729,0.000003550522,0.004307942,0.0002772674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961198,0.0001985513,0.00205872,0.0008552904,0.00009834659,0.0001923313,0.00003304696,0.00004035653,0.0004035621],"genre_scores_gemma":[0.9987738,0.00002627073,0.00006196056,0.0003127154,0.0002627597,0.00002058502,0.0001711556,0.00004634054,0.000324445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004403878,"threshold_uncertainty_score":0.8550687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02537467803815953,"score_gpt":0.2545469595201105,"score_spread":0.2291722814819509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}