{"id":"W3111791445","doi":"10.3390/bioengineering7040164","title":"Toward Spatial Identities in Human Brain Organoids-on-Chip Induced by Morphogen-Soaked Beads","year":2020,"lang":"en","type":"article","venue":"Bioengineering","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Ministry of Science and Technology of the People's Republic of China; Israel Science Foundation; National Natural Science Foundation of China; International Development Research Centre; National Science Foundation; Yale University; Impact Fund; United States-Israel Binational Science Foundation","keywords":"Morphogen; Organoid; Wnt signaling pathway; Biology; Cell biology; Embryonic stem cell; Developmental biology; Neuroscience; Anatomy; Gene; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002356217,0.0004043283,0.0002911496,0.0002322796,0.0002116871,0.0003929759,0.0004350077,0.000288432,0.001114487],"category_scores_gemma":[0.0001927765,0.0003296228,0.0003373348,0.0001683931,0.0003276411,0.0001620528,0.0005273427,0.0005151012,0.0005973937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004169801,"about_ca_system_score_gemma":0.0002751791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032021,"about_ca_topic_score_gemma":0.001984862,"domain_scores_codex":[0.999707,0.00003179236,0.00002334784,0.00009890206,0.00009444152,0.00004445218],"domain_scores_gemma":[0.9998306,0.00004749151,0.00003770344,0.00003132514,0.00002519015,0.00002775809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001687377,0.000006616792,0.00006727324,0.00002435834,0.000003373782,0.00001879702,0.00001877398,0.0001868272,0.9986141,0.00008617288,0.00004968841,0.0009071821],"study_design_scores_gemma":[0.000003296559,0.00001321568,0.0006253537,0.000002138013,0.000005621809,0.00002881669,0.00000830814,0.001178858,0.9968177,0.00002116397,0.001291805,0.000003686423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8728661,0.001760891,0.117954,0.0002509606,0.0001532762,0.0001345621,0.00146611,0.001008434,0.004405787],"genre_scores_gemma":[0.8907533,0.001486499,0.09664015,0.0001665537,0.00001959332,0.0003741362,0.00235584,0.000272206,0.007931679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114487,"threshold_uncertainty_score":0.00372833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02537467803815953,"score_gpt":0.2545469595201105,"score_spread":0.2291722814819509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}