{"id":"W3111817003","doi":"10.1016/s2152-2650(20)30955-1","title":"MM-347: Ixazomib Plus Lenalidomide-Dexamethasone (IRd) vs. Placebo-Rd for Newly Diagnosed Multiple Myeloma (NDMM) Patients Not Eligible for Autologous Stem Cell Transplant: The Double-Blind, Placebo-Controlled, Phase 3 TOURMALINE-MM2 Trial","year":2020,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University; University of Calgary; University of Alberta","funders":"","keywords":"Lenalidomide; Ixazomib; Placebo; Multiple myeloma; Medicine; Dexamethasone; Internal medicine; Double blind; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007314553,0.001391726,0.002031612,0.0003896637,0.0002810669,0.000908208,0.0009293911,0.001368235,0.006484275],"category_scores_gemma":[0.0007204201,0.0004631017,0.00148088,0.0003415458,0.000810297,0.0007083717,0.000383897,0.002734255,0.001009521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008058524,"about_ca_system_score_gemma":0.0009446163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606616,"about_ca_topic_score_gemma":0.003117808,"domain_scores_codex":[0.9997109,0.0001464315,0.00001190643,0.00005299751,0.00002140674,0.00005633888],"domain_scores_gemma":[0.999739,0.00006638732,0.00005762744,0.00001849299,0.00001218908,0.0001063316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9779568,0.002324355,0.0002107527,0.0004267978,0.0005631367,0.00002056601,0.00002046564,0.0002924619,0.003054445,0.0001391372,0.0009724582,0.01401871],"study_design_scores_gemma":[0.9546807,0.0414919,0.001360075,0.00004484199,0.0004331481,0.00002754514,0.00001941665,0.0004201328,0.000504137,0.0001910976,0.0008144851,0.00001247969],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816348,0.009132728,0.0004686829,0.001237266,0.0008144322,0.001465658,0.001598037,0.0002690822,0.003379251],"genre_scores_gemma":[0.9870996,0.003744665,0.0007903079,0.001076625,0.0004723554,0.00126126,0.001286834,0.00002984236,0.004238501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006484275,"threshold_uncertainty_score":0.02169204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09393117564019866,"score_gpt":0.3687681716560343,"score_spread":0.2748369960158356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}