{"id":"W3111832741","doi":"10.1093/neuonc/noaa222.115","title":"DIPG-73. SENESCENCE ASSOCIATED SECRETORY PHENOTYPE AS A MECHANISM OF RESISTANCE AND THERAPEUTIC VULNERABILITY IN BMI1 INHIBITOR TREATED DIPG","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"BMI1; Cancer research; In vivo; Senescence; Apoptosis; Phenotype; Biology; Histone H3; Synthetic lethality; Cell culture; Epigenetics; Cell biology; Gene; Genetics; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008647383,0.0002498835,0.0004090481,0.000280643,0.0001117977,0.0002199905,0.0001831293,0.0002322918,0.002055496],"category_scores_gemma":[0.00007553118,0.00009439238,0.0002579134,0.0002313085,0.0001697835,0.0001076824,0.0001338579,0.0006761614,0.0004093733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003342311,"about_ca_system_score_gemma":0.0001883562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001314422,"about_ca_topic_score_gemma":0.001838227,"domain_scores_codex":[0.9999166,0.000004925841,0.000004828457,0.00001927712,0.00003061613,0.00002371336],"domain_scores_gemma":[0.9999328,0.000007094625,0.00001268508,0.000006178689,0.000008267448,0.00003310302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003204666,0.0001125585,0.0009099509,0.00006686195,0.00001435431,0.0002395926,0.00001533299,0.0001157883,0.9916922,0.00006984694,0.0002785816,0.006164524],"study_design_scores_gemma":[0.00008888532,0.003794555,0.03647231,0.00001075943,0.00006663268,0.002123842,0.00006766353,0.001704305,0.9484326,0.000109415,0.007114776,0.00001443436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934943,0.00168785,0.001276947,0.0001401244,0.00003901577,0.00007731793,0.001500826,0.0002550352,0.001528589],"genre_scores_gemma":[0.9933697,0.0007246759,0.001101098,0.0001078506,0.000005906839,0.00006520109,0.001937539,0.00003155132,0.002656546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002055496,"threshold_uncertainty_score":0.00687629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274465836879174,"score_gpt":0.2911998042658498,"score_spread":0.2637532205779324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}