{"id":"W3111852362","doi":"10.7554/elife.58952.sa1","title":"Decision letter: TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte–tracheal interactions","year":2020,"lang":"en","type":"peer-review","venue":"","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Astrocyte; Lipid microdomain; Neuroscience; Cell biology; Chemistry; Biology; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003489814,0.0008671702,0.0009144706,0.0001270419,0.0001562377,0.00008032376,0.0009382368,0.0006101312,0.0009220578],"category_scores_gemma":[0.0006000221,0.0008466359,0.0008767194,0.0002847816,0.0001482154,0.000009091769,0.0003042618,0.0008543814,0.0003866182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000122655,"about_ca_system_score_gemma":0.0003923214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004393613,"about_ca_topic_score_gemma":0.0001457398,"domain_scores_codex":[0.9957211,0.0002756882,0.001065292,0.001539617,0.0006797512,0.0007185776],"domain_scores_gemma":[0.9974086,0.0001092716,0.0004274388,0.001157227,0.0003143966,0.0005830972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003836948,0.0001272119,0.00001007607,0.0005463344,0.0002607044,0.00005022404,0.00001443108,0.00002655911,0.1275032,0.000001246976,0.8663492,0.004727178],"study_design_scores_gemma":[0.001200614,0.0002666128,0.00003277954,0.00125361,0.0003853286,0.000055638,0.000007956246,0.00004098653,0.05729594,0.000007996834,0.9387438,0.0007087141],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.1435453,0.2399276,0.2105214,0.2540818,0.05343498,0.01711453,0.0451711,0.002126566,0.03407663],"genre_scores_gemma":[0.1325372,0.01627785,0.05205437,0.1553527,0.02118443,0.00139659,0.1959261,0.001864295,0.4234065],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.3893299,"threshold_uncertainty_score":0.9999912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029826000474018,"score_gpt":0.2944554458686013,"score_spread":0.2741571858638611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}