{"id":"W3111906653","doi":"10.1002/alz.041330","title":"Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Degron; Transgene; Ubiquitin ligase; KEAP1; Cell biology; Biology; Neurodegeneration; Genetically modified mouse; Ubiquitin; Cre recombinase; Proteasome; Molecular biology; Chemistry; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008698044,0.001226663,0.001013687,0.002124758,0.000670904,0.0006699216,0.001239408,0.002113237,0.008509371],"category_scores_gemma":[0.0004429579,0.0008616471,0.0009888116,0.0006802318,0.0007538175,0.0009745484,0.0006204433,0.00294897,0.002977233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000612839,"about_ca_system_score_gemma":0.0004633909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007369358,"about_ca_topic_score_gemma":0.001161684,"domain_scores_codex":[0.9988295,0.00009797662,0.0001686545,0.0004620763,0.0002784437,0.0001634446],"domain_scores_gemma":[0.9990931,0.00009204277,0.0002540701,0.0001319619,0.0001847876,0.0002440295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002523964,0.0003882638,0.0006000996,0.0001123165,0.00002211245,0.0002836003,0.0001024136,0.00009152026,0.9936177,0.0006069753,0.000662525,0.003260075],"study_design_scores_gemma":[0.0002525775,0.001351149,0.005970863,0.0001022462,0.0002077785,0.002265219,0.0001736258,0.00303602,0.9503934,0.0006170191,0.03556272,0.00006747567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7563797,0.003531387,0.199574,0.002031186,0.00160946,0.002649436,0.0190405,0.005013917,0.01017033],"genre_scores_gemma":[0.7137001,0.004261807,0.141856,0.001272477,0.0003186357,0.009144054,0.02229659,0.001728771,0.1054215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008509371,"threshold_uncertainty_score":0.02846664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074519218203201,"score_gpt":0.2553045516361825,"score_spread":0.2245593594541505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}