{"id":"W3111907072","doi":"10.1093/neuonc/noaa222.831","title":"TBIO-02. IMMUNE PROFILING OF RARE EMBRYONAL BRAIN TUMORS REVEAL EVIDENCE OF DYSREGULATED INTERFERON SIGNALLING AS A POTENTIAL DETERMINANT OF IMMUNOLOGICAL HETEROGENEITY","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Biology; In silico; Immune system; Glioma; Epigenomics; Transcriptome; Immunotherapy; Tumor microenvironment; Computational biology; Cancer research; Immunology; DNA methylation; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713111,0.000178126,0.0002238879,0.0003347621,0.0002358903,0.0003701549,0.0001973387,0.0002335263,0.001459892],"category_scores_gemma":[0.0001542836,0.0001039906,0.0001762576,0.0002754101,0.0001687715,0.00008093221,0.0001663162,0.0005317156,0.0004179673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002268746,"about_ca_system_score_gemma":0.0001712912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009184136,"about_ca_topic_score_gemma":0.001740906,"domain_scores_codex":[0.9997939,0.00002029761,0.00001163549,0.00005029024,0.00007003074,0.00005374044],"domain_scores_gemma":[0.9998437,0.00002739986,0.00004395774,0.00001487039,0.00001979115,0.00005019983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002760067,0.00002598449,0.005066313,0.00003177395,0.00001403131,0.00008955337,0.0000301117,0.0001019866,0.9922002,0.00004983911,0.0001603276,0.001953794],"study_design_scores_gemma":[0.00003560232,0.0007540687,0.2215924,0.00001876708,0.00008019021,0.00212616,0.0003003149,0.00337744,0.7627987,0.0002602166,0.008637575,0.00001859851],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919752,0.000653638,0.00254359,0.00006526784,0.00001412127,0.00002716957,0.003470561,0.0001002951,0.00115029],"genre_scores_gemma":[0.9860763,0.0003722282,0.002433577,0.0001527235,0.000006529917,0.00008295725,0.008922595,0.00006271253,0.001890258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459892,"threshold_uncertainty_score":0.004883826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03337780965469066,"score_gpt":0.2987804849533806,"score_spread":0.2654026752986899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}