{"id":"W3111926312","doi":"10.1093/neuonc/noaa222.132","title":"EPCT-08. ACTIVITY OF LAROTRECTINIB IN PEDIATRIC TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION CANCER PATIENTS WITH PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Internal medicine; Adverse effect; Tropomyosin receptor kinase A; Fusion gene; Oncology; Cancer; Gastroenterology; Receptor; Neurotrophin; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005641994,0.0002438336,0.0005843583,0.0002009773,0.0001510331,0.0005235947,0.000219923,0.000273477,0.00321321],"category_scores_gemma":[0.0005810036,0.00007873322,0.0003865226,0.0003911915,0.0001845103,0.0002903341,0.0001841148,0.0006063701,0.0006302236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007465005,"about_ca_system_score_gemma":0.0007687221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001074364,"about_ca_topic_score_gemma":0.00281796,"domain_scores_codex":[0.9997779,0.00006566915,0.00002740841,0.00004072989,0.00004433957,0.00004404905],"domain_scores_gemma":[0.9996524,0.00007408599,0.00009225155,0.00001863992,0.00006008536,0.000102539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05009912,0.002598628,0.3156359,0.002043095,0.001082593,0.007199007,0.0003051196,0.004905417,0.1008928,0.001197226,0.03653659,0.4775046],"study_design_scores_gemma":[0.02664236,0.07343388,0.651089,0.0005171073,0.002089544,0.03329908,0.000312851,0.008707814,0.09582717,0.0008275532,0.1071674,0.00008623009],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970383,0.01096021,0.000716426,0.0006470043,0.00006181402,0.0003331827,0.0043611,0.0001427422,0.01239459],"genre_scores_gemma":[0.989493,0.002472595,0.001075499,0.000417841,0.00004921673,0.0001482306,0.004880474,0.00001671509,0.001446399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00321321,"threshold_uncertainty_score":0.01074922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315751926474354,"score_gpt":0.2512920259977259,"score_spread":0.2381345067329823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}