{"id":"W3111943351","doi":"10.1038/s41598-020-79144-x","title":"MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Cancer Society Research Institute; Terry Fox Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Protoporphyrin IX; Ferrochelatase; Cancer research; Chemistry; MAPK/ERK pathway; Cancer cell; Downregulation and upregulation; Cancer; Gene knockdown; HRAS; Kinase; Photodynamic therapy; Cell biology; Molecular biology; Biology; Biochemistry; Mutation; Heme; Apoptosis; Enzyme; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008714262,0.0001761024,0.0002986848,0.00006203465,0.0006841205,0.0002304096,0.0001373513,0.00005627025,0.000265191],"category_scores_gemma":[0.0003373969,0.0001111223,0.00008457967,0.0007319986,0.0007283806,0.0002329627,0.0001592692,0.0002495669,0.0000162343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009055126,"about_ca_system_score_gemma":0.0001963897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001384917,"about_ca_topic_score_gemma":0.00004984188,"domain_scores_codex":[0.9975353,0.00007502474,0.0004172031,0.0007790427,0.0008258309,0.000367625],"domain_scores_gemma":[0.9986831,0.0001053805,0.0002103155,0.0006091201,0.0002322413,0.0001598482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002396138,0.0001037574,0.006649845,0.0001431108,0.0002626327,0.0005789287,0.01707906,0.00009237383,0.8265916,0.0001858862,0.1269278,0.02114532],"study_design_scores_gemma":[0.0009851052,0.0002688957,0.03490554,0.0002395213,0.0001312293,0.0004119623,0.003796784,0.001170086,0.2109798,0.009577927,0.7370722,0.0004609667],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700364,0.006948526,0.00005639115,0.01813598,0.001998648,0.0008520787,0.00000803717,0.0001102438,0.001853659],"genre_scores_gemma":[0.9949253,0.0009361409,0.0002021208,0.0003008532,0.00029628,0.00006297557,0.00003022664,0.00002130211,0.003224841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6156119,"threshold_uncertainty_score":0.526177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09521394551973195,"score_gpt":0.3808466853797786,"score_spread":0.2856327398600467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}