{"id":"W3111961654","doi":"10.1212/wnl.92.15_supplement.p3.2-095","title":"Evaluating the efficacy and safety of 6-week extended interval dosing of natalizumab via a prospective, controlled, randomized, open-label, rater-blinded phase 3b study (P3.2-095)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; Dosing; Natalizumab; Open label; Randomized controlled trial; Prospective cohort study; Confidence interval; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001469315,0.0002437034,0.001669633,0.0001393944,0.00009919809,0.00002209109,0.0002599441,0.0001277125,0.0001583376],"category_scores_gemma":[0.0008514561,0.0001404007,0.0001332917,0.0001898346,0.0004093526,0.00008874234,0.0002834255,0.0003870019,0.000007920864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000146843,"about_ca_system_score_gemma":0.0001485514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001861164,"about_ca_topic_score_gemma":0.000009447283,"domain_scores_codex":[0.9967611,0.001254706,0.0009196505,0.0004658455,0.0003143741,0.000284308],"domain_scores_gemma":[0.9971667,0.001510523,0.000542826,0.0004848792,0.0001930305,0.0001020365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9542247,0.00764961,0.001276598,0.00006572125,0.0009853181,0.00006428704,0.0009408509,0.00002914256,0.02686637,0.0001602491,0.000008097742,0.007729077],"study_design_scores_gemma":[0.9401833,0.03518537,0.005413251,0.00008248111,0.001486124,0.000149931,0.0001067243,0.016155,0.0008576319,0.0002389281,0.00001352699,0.0001276852],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886385,0.001243333,0.00005775447,0.0004346472,0.0002973937,0.008566992,0.00001482827,0.00002527597,0.0007213053],"genre_scores_gemma":[0.9991947,0.00005337338,0.00006359527,0.0003742892,0.00004221608,0.0001286208,0.000006364307,0.00002963011,0.0001071865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02753576,"threshold_uncertainty_score":0.5725374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05233229574306807,"score_gpt":0.3959548832673233,"score_spread":0.3436225875242552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}