{"id":"W3111961654","doi":"10.1212/wnl.92.15_supplement.p3.2-095","title":"Evaluating the efficacy and safety of 6-week extended interval dosing of natalizumab via a prospective, controlled, randomized, open-label, rater-blinded phase 3b study (P3.2-095)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; Dosing; Natalizumab; Open label; Randomized controlled trial; Prospective cohort study; Confidence interval; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009568266,0.001179704,0.001799898,0.0003921516,0.0007139692,0.001135644,0.0009330421,0.002080192,0.004047916],"category_scores_gemma":[0.005589048,0.0006341197,0.001530087,0.0005793552,0.001113316,0.001255552,0.000428683,0.003219422,0.0008195704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007145688,"about_ca_system_score_gemma":0.003100612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005709071,"about_ca_topic_score_gemma":0.001414167,"domain_scores_codex":[0.9958286,0.002805003,0.0003415295,0.0004070261,0.0003745922,0.000243363],"domain_scores_gemma":[0.9958289,0.001097496,0.001471153,0.000599088,0.0003565336,0.0006467621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9345682,0.0234843,0.001593326,0.0004208355,0.00102127,0.00002122556,0.00006726948,0.0003540206,0.008279455,0.0002116418,0.0006377377,0.0293407],"study_design_scores_gemma":[0.7209224,0.2708398,0.003685103,0.00004091731,0.0004826314,0.00003674403,0.00001574878,0.0004688257,0.001956947,0.0001828352,0.001346441,0.00002164799],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550989,0.005197531,0.006582496,0.0006306003,0.0007000835,0.02625292,0.002015201,0.0002244781,0.003297739],"genre_scores_gemma":[0.9638433,0.001784979,0.01302385,0.001318555,0.0005536826,0.0164268,0.001052583,0.00005061095,0.00194562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009568266,"threshold_uncertainty_score":0.05060238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05233229574306807,"score_gpt":0.3959548832673233,"score_spread":0.3436225875242552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}