{"id":"W3112001372","doi":"10.1093/neuonc/noaa215.233","title":"CTNI-67. EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN EXPANDED DATASET","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Internal medicine; Oncology; Surgery; Receptor; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001395397,0.0006146814,0.001366822,0.0006920265,0.0002659685,0.0007901852,0.0008720688,0.0004635864,0.004396216],"category_scores_gemma":[0.002201488,0.000232062,0.001801142,0.001417032,0.00019294,0.0004341605,0.0005299718,0.0007162321,0.001371881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007410647,"about_ca_system_score_gemma":0.001111204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003588276,"about_ca_topic_score_gemma":0.01099894,"domain_scores_codex":[0.9989535,0.0002721749,0.0001590348,0.0002441331,0.0002263248,0.0001447943],"domain_scores_gemma":[0.998223,0.0004670265,0.0006596745,0.0001997566,0.0002790799,0.0001714577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08499182,0.0008191678,0.5711767,0.0102627,0.01249811,0.001430829,0.000281883,0.006557021,0.01207363,0.0006382381,0.1034272,0.1958427],"study_design_scores_gemma":[0.01854588,0.005901391,0.8594461,0.001572472,0.01051427,0.003892621,0.0002308041,0.006522495,0.003974134,0.0009306955,0.08833706,0.0001320233],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6637022,0.01509605,0.001119569,0.0006321655,0.00007743748,0.0008521526,0.3077933,0.0001623719,0.0105646],"genre_scores_gemma":[0.6614166,0.003110455,0.001057163,0.0006026502,0.0001161392,0.0007830689,0.3302201,0.000052012,0.002641732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004396216,"threshold_uncertainty_score":0.01470685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492376473046511,"score_gpt":0.2570931674712836,"score_spread":0.2421694027408185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}