{"id":"W3112014125","doi":"10.1016/j.molcel.2020.11.011","title":"The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Genome; DNA; Chromosome; Effector; Cell biology; Genetics; Gene; ATP hydrolysis; Computational biology; ATPase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004413142,0.0003478565,0.0004410263,0.0002594554,0.0003657256,0.0009079839,0.0004316971,0.0004649327,0.0009321314],"category_scores_gemma":[0.0005187943,0.0002994835,0.0002864993,0.0001994273,0.0003350082,0.000563832,0.0006533777,0.0006011557,0.0008694743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004402161,"about_ca_system_score_gemma":0.0003728767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004152582,"about_ca_topic_score_gemma":0.0006192219,"domain_scores_codex":[0.9997436,0.0000302747,0.0000197073,0.00006715852,0.0001039775,0.00003529683],"domain_scores_gemma":[0.9996945,0.00002803379,0.00007371663,0.00005011285,0.00003967024,0.0001139351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000232706,0.00002761757,0.001183076,0.00008616842,0.00001848802,0.00007963593,0.00003033156,0.000383828,0.9816327,0.002708832,0.0003713521,0.01324517],"study_design_scores_gemma":[0.00001754446,0.0002588728,0.01100919,0.00001353261,0.00002028744,0.0005763543,0.00004184539,0.005367146,0.9714254,0.001062268,0.01018277,0.00002474691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503727,0.005256047,0.03951248,0.0003399965,0.0001664714,0.00004106146,0.0002466979,0.0008320331,0.00323262],"genre_scores_gemma":[0.9820976,0.0005775311,0.01349882,0.00007885047,0.00003678456,0.000008758523,0.0005937521,0.00004620947,0.003061739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009321314,"threshold_uncertainty_score":0.003193974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02339144256770535,"score_gpt":0.2344716751600969,"score_spread":0.2110802325923915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}