{"id":"W3112027773","doi":"10.1093/neuonc/noaa215.989","title":"LTBK-04. PHASE 2 MULTICENTER STUDY OF THE ONCOLYTIC ADENOVIRUS DNX-2401 (TASADENOTUREV) IN COMBINATION WITH PEMBROLIZUMAB FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"","keywords":"Pembrolizumab; Temozolomide; Medicine; Phases of clinical research; Regimen; Internal medicine; Adverse effect; Surgery; Oncology; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000413649,0.0003195821,0.0005079772,0.0001240855,0.000123169,0.00002036101,0.000645338,0.0001868358,0.00002190475],"category_scores_gemma":[0.0005164247,0.0002277967,0.0001147638,0.0004390646,0.0001664632,0.00001071976,0.0002955976,0.0004761806,0.000006503692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915783,"about_ca_system_score_gemma":0.0005622653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004903579,"about_ca_topic_score_gemma":0.003544689,"domain_scores_codex":[0.9966696,0.001053471,0.0005441887,0.0007914545,0.0004377451,0.0005035416],"domain_scores_gemma":[0.9984484,0.0001919498,0.0003140419,0.0005619777,0.0002880639,0.0001955726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1647063,0.02129469,0.005579774,0.00007599595,0.0003387244,0.0001037103,0.0094188,0.0008843142,0.7783298,0.000005486543,0.001184303,0.018078],"study_design_scores_gemma":[0.08996191,0.5811447,0.002947058,0.0000274556,0.0002297048,0.00001907359,0.007282691,0.002152778,0.3058332,0.00001371726,0.00988239,0.0005053266],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925377,0.000140824,0.00007750055,0.001405675,0.0002281997,0.005481523,0.00005333323,0.00001701832,0.00005818182],"genre_scores_gemma":[0.9980373,0.00002417878,0.00003543916,0.00104745,0.0001545915,0.0005985699,0.00002004674,0.00006301658,0.00001937817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.55985,"threshold_uncertainty_score":0.928928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219008510426249,"score_gpt":0.3487269940795363,"score_spread":0.3165369089752739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}