{"id":"W3112027773","doi":"10.1093/neuonc/noaa215.989","title":"LTBK-04. PHASE 2 MULTICENTER STUDY OF THE ONCOLYTIC ADENOVIRUS DNX-2401 (TASADENOTUREV) IN COMBINATION WITH PEMBROLIZUMAB FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"","keywords":"Pembrolizumab; Temozolomide; Medicine; Phases of clinical research; Regimen; Internal medicine; Adverse effect; Surgery; Oncology; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002378358,0.00176894,0.001324585,0.0004524399,0.0004916136,0.0009337951,0.001435794,0.001114003,0.003567382],"category_scores_gemma":[0.0006013018,0.0007561081,0.0007451327,0.0003948904,0.0007555691,0.0006052194,0.0003013116,0.002220619,0.001294625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00119821,"about_ca_system_score_gemma":0.001766219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002255715,"about_ca_topic_score_gemma":0.005333167,"domain_scores_codex":[0.9993219,0.0003982584,0.00002459738,0.000095155,0.00005808903,0.0001020373],"domain_scores_gemma":[0.9994988,0.00005261887,0.0001127405,0.00005102263,0.00004511706,0.0002395928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5677087,0.1234518,0.0126567,0.0009606304,0.001481336,0.0005717191,0.000373375,0.002302906,0.176781,0.0003704051,0.007788111,0.1055532],"study_design_scores_gemma":[0.4025546,0.5620084,0.01491957,0.00004034308,0.0005463283,0.0005515434,0.00007819115,0.001165533,0.01366614,0.0001120175,0.004324402,0.00003293878],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906651,0.002305697,0.0007373453,0.0003339079,0.0001113189,0.002580503,0.001347823,0.0001666911,0.00175156],"genre_scores_gemma":[0.9855467,0.001404518,0.002379337,0.0006261962,0.0001476212,0.003391692,0.003274998,0.00003972455,0.003189117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003567382,"threshold_uncertainty_score":0.01257813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219008510426249,"score_gpt":0.3487269940795363,"score_spread":0.3165369089752739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}