{"id":"W3112064555","doi":"10.1158/1055-9965.epi-20-1319","title":"CanRisk Tool—A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants","year":2021,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Cancer Research UK; Government of Canada; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada","keywords":"Ovarian cancer; Breast cancer; Genetic variants; Genetic testing; Cancer; Case-control study; Risk factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001494307,0.0001634419,0.0003238331,0.00003484367,0.0001652763,0.000007351572,0.0001454681,0.0002053763,0.00002697126],"category_scores_gemma":[0.0004254276,0.0001164295,0.0001547592,0.000129136,0.0006172352,0.000008274326,0.0001370088,0.0001054926,1.086919e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006091634,"about_ca_system_score_gemma":0.0004736522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008168707,"about_ca_topic_score_gemma":0.001368413,"domain_scores_codex":[0.9979137,0.000765475,0.000567555,0.0004519407,0.00006685698,0.0002345149],"domain_scores_gemma":[0.9984249,0.0003827275,0.0005262649,0.0003906781,0.0002347149,0.00004066945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001922949,0.00007012437,0.3054329,0.0003028726,0.003695969,6.185174e-7,0.0005113935,0.00174155,0.4097388,0.0002729222,0.003726745,0.2725832],"study_design_scores_gemma":[0.005963129,0.0002568438,0.940571,0.00029401,0.001968283,0.0001084734,0.0007594098,0.01340255,0.02638366,0.006436079,0.003549159,0.0003074551],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7965391,0.1456743,0.05226284,0.002510087,0.0009022358,0.0008735118,0.001212511,0.000007901635,0.00001743671],"genre_scores_gemma":[0.9665354,0.02967727,0.002828678,0.0001200126,0.0002001716,0.0004916376,0.00005787867,0.00002088814,0.00006800567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6351381,"threshold_uncertainty_score":0.4747857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864323546636203,"score_gpt":0.3066328511309064,"score_spread":0.2879896156645444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}