{"id":"W3112140683","doi":"10.3390/ijms21249692","title":"Lipidation of Antimicrobial Peptides as a Design Strategy for Future Alternatives to Antibiotics","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lipid-anchored protein; Antimicrobial; Antibacterial peptide; Peptide; Toxicity; Antimicrobial peptides; Antibiotics; Chemistry; Lysine; Drug; Bacteria; Antibacterial activity; Antibiotic resistance; Biochemistry; Combinatorial chemistry; Biology; Pharmacology; Amino acid; Genetics; Autophagy; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004999995,0.0002739585,0.0009573714,0.0004542891,0.000084543,0.0001070351,0.001243399,0.0001970676,0.0000322132],"category_scores_gemma":[0.0002053953,0.0002082516,0.0005868798,0.0002181108,0.000317423,0.0002210168,0.0001260633,0.0002653617,0.0000254998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005223802,"about_ca_system_score_gemma":0.0007537521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001250645,"about_ca_topic_score_gemma":0.000001196051,"domain_scores_codex":[0.9982899,0.0002108422,0.000837829,0.0002766017,0.000176884,0.0002079384],"domain_scores_gemma":[0.9977634,0.0002338154,0.00135015,0.00008850197,0.0005258196,0.00003834071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002612713,0.0002106386,0.000003369728,0.0008424835,0.001899458,0.00008652443,0.0005745656,0.0007804243,0.09908582,0.003858882,0.003936001,0.8884606],"study_design_scores_gemma":[0.0007206378,0.001851722,0.000003269867,0.007039769,0.0005407555,0.001169123,0.0006685597,0.000007556103,0.1571599,0.0003904758,0.8299474,0.0005008149],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001966214,0.9568675,0.03571642,0.0007646162,0.003642864,0.0006330789,0.0002419477,0.00001204415,0.0001553156],"genre_scores_gemma":[0.0207067,0.9682721,0.009987975,0.0002333734,0.0006098691,0.000001663954,0.00004132794,0.00002817664,0.0001187561],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8879597,"threshold_uncertainty_score":0.8492256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05371216858000595,"score_gpt":0.3543317423551119,"score_spread":0.300619573775106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}