{"id":"W3112176049","doi":"10.3389/fmolb.2020.595474","title":"Homology-Directed Repair in Zebrafish: Witchcraft and Wizardry?","year":2020,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Heart and Stroke Foundation of Canada","keywords":"Zebrafish; CRISPR; Computational biology; Mutagenesis; Biology; Genome editing; Gene; Palindrome; Genetics; Zinc finger nuclease; Mutant; Homology (biology); Homology modeling; Model organism; Genome; Genetic screen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002967806,0.0004085214,0.0009203213,0.0003388581,0.00003856848,0.00002968452,0.0004560139,0.0004352164,0.000002416985],"category_scores_gemma":[0.0002194831,0.0003839218,0.0002296861,0.0007830887,0.0002776874,0.000004770765,0.0002546312,0.0002963137,0.000001763086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003707473,"about_ca_system_score_gemma":0.0002241125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002355886,"about_ca_topic_score_gemma":0.00004397185,"domain_scores_codex":[0.9977641,0.0001641672,0.000467058,0.0009909041,0.0001772415,0.0004365864],"domain_scores_gemma":[0.9993677,0.0000119909,0.0001101669,0.0003615684,0.00001855921,0.0001300139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005159287,0.000212934,0.0039999,0.007562763,0.0004194732,0.001223137,0.0003074108,0.0001341811,0.0094826,0.00007121859,0.0177653,0.9587695],"study_design_scores_gemma":[0.0002473948,0.0001630517,0.000121374,0.0008260791,0.00008090841,0.00006308428,0.00007335686,0.0002786684,0.0007410503,0.00004640998,0.9967711,0.00058753],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005693599,0.993365,0.004719721,0.00005701345,0.0006138282,0.0004658603,0.00002922799,0.00004560213,0.0001343784],"genre_scores_gemma":[0.0003888058,0.9828757,0.0163284,0.0001103187,0.00007038051,0.00006442467,0.00005802636,0.0000410108,0.00006294194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9790058,"threshold_uncertainty_score":0.9998612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00821499841811637,"score_gpt":0.295630167602064,"score_spread":0.2874151691839476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}