{"id":"W3112179900","doi":"10.1056/nejmoa2031054","title":"CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1856,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; BC Children's Hospital; University of British Columbia","funders":"BC Children's Hospital; St. Jude Children's Research Hospital","keywords":"CRISPR; Thalassemia; Genome editing; Disease; Cas9; Medicine; Biology; Gene; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004802805,0.0004233574,0.0004674209,0.0002746801,0.000266607,0.0004601425,0.0004561554,0.0006880636,0.004564257],"category_scores_gemma":[0.0004290213,0.0002384223,0.0004695453,0.0002094161,0.0003083381,0.0001910482,0.0004555308,0.0008644863,0.0007170079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004084379,"about_ca_system_score_gemma":0.000569445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062239,"about_ca_topic_score_gemma":0.001977752,"domain_scores_codex":[0.9996011,0.00008045174,0.00004099288,0.00009495908,0.0001338911,0.00004865657],"domain_scores_gemma":[0.9998267,0.00005047371,0.00004892168,0.00002128189,0.00001905395,0.00003365976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001199931,0.000266411,0.001867615,0.001467416,0.000253661,0.001889727,0.0001812064,0.003322483,0.8334466,0.008755115,0.02701581,0.120334],"study_design_scores_gemma":[0.0008685001,0.002801647,0.009482619,0.0003720549,0.0004838594,0.01137033,0.0001067716,0.01770115,0.6363814,0.003431649,0.316863,0.0001371191],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5886543,0.0425113,0.2848785,0.00475488,0.002248452,0.002201428,0.01639203,0.009736815,0.0486223],"genre_scores_gemma":[0.8942175,0.01156519,0.06820422,0.001222758,0.0001189952,0.0009554683,0.00778464,0.0003585647,0.01557262],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004564257,"threshold_uncertainty_score":0.01526898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668992070907199,"score_gpt":0.2601342652765965,"score_spread":0.2434443445675245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}