{"id":"W3112221778","doi":"10.1183/13993003.03764-2020","title":"TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection","year":2020,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Respiratory viral infections research","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Universidade Estadual de Campinas; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Necroptosis; Bronchiolitis; Medicine; Tumor necrosis factor alpha; Alveolar macrophage; Immunology; Macrophage; Virus; Pathogenesis; Respiratory system; Programmed cell death; Virology; Biology; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001645416,0.0006528025,0.0007051724,0.0008284795,0.001302352,0.0004453177,0.0004665085,0.0001755446,0.001509282],"category_scores_gemma":[0.003184029,0.0006080099,0.0006549457,0.001336368,0.0003689525,0.0008065085,0.0003804911,0.002146309,0.002690387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004707714,"about_ca_system_score_gemma":0.000746068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001058628,"about_ca_topic_score_gemma":0.000004565495,"domain_scores_codex":[0.9925672,0.002649805,0.001402089,0.0009614709,0.001396096,0.00102332],"domain_scores_gemma":[0.9948955,0.0001295628,0.0005233157,0.0008058911,0.0006338598,0.003011922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001671151,0.0003467281,0.2110659,0.0002660933,0.0002711253,0.009841319,0.0002424838,0.0003019295,0.7652331,0.000009944585,0.003103588,0.007646661],"study_design_scores_gemma":[0.004395182,0.001599138,0.7808021,0.0002254561,0.0002471002,0.0002073552,0.00005393352,0.00008358722,0.04066899,0.000004211917,0.1710325,0.0006804393],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916796,0.00261645,0.0005892343,0.0004239597,0.0004932046,0.0006737309,0.00006125173,0.0004853633,0.002977171],"genre_scores_gemma":[0.987705,0.0004951199,0.0001116146,0.007067256,0.004065635,0.00002843834,0.00001316878,0.0003139401,0.0001998629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7245641,"threshold_uncertainty_score":0.9999978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04677870975520811,"score_gpt":0.3098827179121782,"score_spread":0.2631040081569701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}