{"id":"W3112228865","doi":"10.1101/2020.12.07.415273","title":"GLI3 Processing by the Primary Cilium Regulates Muscle Stem Cell Entry into G <sub>Alert</sub>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine; Agence Nationale de la Recherche; Stem Cell Network; Fondation pour la Recherche Médicale; French Muscular Dystrophy Association; Muscular Dystrophy Association","keywords":"GLI3; Cell biology; Stem cell; Cilium; Satellite; Biology; Cell division; Cell growth; Cell; Chemistry; Transcription factor; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007661305,0.0001617008,0.0001812739,0.0001871751,0.0001714396,0.0002716556,0.0001462185,0.0002215452,0.001638695],"category_scores_gemma":[0.00009784631,0.0001453185,0.0001730194,0.000110536,0.0002628538,0.0001362098,0.0002001884,0.0003715875,0.000700652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003943049,"about_ca_system_score_gemma":0.0003083078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001469106,"about_ca_topic_score_gemma":0.002079318,"domain_scores_codex":[0.9999291,0.000006716044,0.0000045453,0.00001319993,0.00001925682,0.00002718318],"domain_scores_gemma":[0.9999248,0.00001225272,0.00002080169,0.000006248253,0.000008095408,0.00002774094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001390218,0.000006253536,0.0004108222,0.00001843314,0.000001634516,0.00007205252,0.00001267189,0.00002591094,0.9987032,0.0001152639,0.00006771588,0.000426939],"study_design_scores_gemma":[0.00001529507,0.00005499122,0.01873715,0.000004825165,0.000005509996,0.0001564698,0.00003715931,0.001103521,0.978704,0.0000990503,0.001079059,0.000002996616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954039,0.0005932546,0.001551202,0.0001139287,0.00001931328,0.000008689351,0.0004986887,0.0001012674,0.001709792],"genre_scores_gemma":[0.9947091,0.0002852242,0.001386932,0.00005734413,0.000006208559,0.00001206652,0.0005333438,0.00004613042,0.00296364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001638695,"threshold_uncertainty_score":0.005481958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006405760381654634,"score_gpt":0.1866322407356714,"score_spread":0.1802264803540167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}