{"id":"W3112255091","doi":"10.1021/acsomega.0c05117","title":"Enhanced Affinity for 3-Amino-Chromane-Derived σ<sub>1</sub> Receptor Ligands","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Eye Institute; Foundation Fighting Blindness","keywords":"Chemistry; Receptor; Stereochemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250622,0.0002770955,0.0003177283,0.00009501822,0.0001451205,0.0003866325,0.0003489341,0.0003215021,0.005486102],"category_scores_gemma":[0.0002033263,0.00009092699,0.0001568824,0.0001427481,0.000205407,0.0002408924,0.0001339647,0.0006726845,0.001620054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003833649,"about_ca_system_score_gemma":0.0002512735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007544926,"about_ca_topic_score_gemma":0.001310467,"domain_scores_codex":[0.9998206,0.00003535116,0.00000851789,0.0000319482,0.00003821052,0.00006540813],"domain_scores_gemma":[0.9999061,0.00003488881,0.00001270036,0.00001101458,0.00001560794,0.00001967706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002624642,0.00002464175,0.0001042133,0.00005775445,0.000006521966,0.00003685472,0.00001499698,0.00005303654,0.9968195,0.0002645565,0.0001579995,0.002197328],"study_design_scores_gemma":[0.00003173936,0.0004330145,0.002439919,0.00000936735,0.00001992554,0.0006684196,0.00004352566,0.0004415688,0.9913433,0.00008711946,0.004472944,0.000009041871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979251,0.003459814,0.004109891,0.0002797229,0.0001296685,0.00005042554,0.0005544919,0.0001951219,0.01196978],"genre_scores_gemma":[0.985833,0.001682903,0.003015836,0.0002631562,0.00002914316,0.00003453155,0.0007359515,0.00003732269,0.008368048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005486102,"threshold_uncertainty_score":0.01835281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879993473308448,"score_gpt":0.2589711487290257,"score_spread":0.2401712139959412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}