{"id":"W3112255091","doi":"10.1021/acsomega.0c05117","title":"Enhanced Affinity for 3-Amino-Chromane-Derived σ<sub>1</sub> Receptor Ligands","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Eye Institute; Foundation Fighting Blindness","keywords":"Chemistry; Receptor; Stereochemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001369272,0.0002251263,0.0002391524,0.00001793305,0.0001177416,0.00002877834,0.0002596829,0.0002371232,0.0000193198],"category_scores_gemma":[0.000396076,0.000205028,0.0001513364,0.0001110479,0.00004949463,0.000006853587,0.0001534083,0.0001237573,0.00008491232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001546887,"about_ca_system_score_gemma":0.00005256883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.887349e-7,"about_ca_topic_score_gemma":0.000001939799,"domain_scores_codex":[0.9987634,0.00003748497,0.0001944971,0.0004922826,0.0001237206,0.0003886347],"domain_scores_gemma":[0.999324,0.00005428771,0.00008682855,0.0001821193,0.00008591218,0.0002669011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003365862,0.00006229428,0.000006238297,0.00004018549,0.00005361295,0.00000167572,0.00004529359,0.00001124824,0.9851713,0.00005494302,0.009553535,0.004663052],"study_design_scores_gemma":[0.001147566,0.001308159,0.00009058345,0.000007735281,0.0000257124,0.000001149621,0.00002215531,0.00003547833,0.9771234,0.00007644005,0.01988918,0.0002723789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939994,0.000207357,0.003995745,0.000584272,0.0003641791,0.0004694339,0.00005194729,0.00006002992,0.0002676634],"genre_scores_gemma":[0.9949906,0.0003080865,0.0005533308,0.002954159,0.0007328545,0.0001610748,0.0002143115,0.00003556019,0.00004997323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01033565,"threshold_uncertainty_score":0.8360798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879993473308448,"score_gpt":0.2589711487290257,"score_spread":0.2401712139959412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}