{"id":"W3112255487","doi":"10.1523/jneurosci.1980-20.2020","title":"Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Trace Elements in Health","field":"Nursing","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Alzheimer Society; Alzheimer's Society; Biotechnology and Biological Sciences Research Council; University of Southern California; Pfizer; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Medical Research Council; Meso Scale Diagnostics; University of Manchester; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Zinc deficiency (plant disorder); Alzheimer's disease; Microglia; Disease; Inflammation; Inflammasome; Medicine; Neuroinflammation; Cognitive decline; Zinc; Immunology; Amyloid beta; Internal medicine; Dementia; Pathology; Micronutrient; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004166123,0.0001267201,0.0001685228,0.00008772387,0.000250583,0.0001468201,0.0002831622,0.0000303467,0.00002054992],"category_scores_gemma":[0.0006769804,0.0001079926,0.00007916896,0.0003582847,0.0001111707,0.001159144,0.00008012653,0.0003345754,0.00000630145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001350271,"about_ca_system_score_gemma":0.0003408094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004210405,"about_ca_topic_score_gemma":0.00000410926,"domain_scores_codex":[0.9973466,0.0002385533,0.0005931269,0.0002621801,0.001134359,0.0004251912],"domain_scores_gemma":[0.9984211,0.00008861414,0.000653048,0.0002609816,0.0002397483,0.0003365435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001317093,0.001002118,0.08094434,0.0001799826,0.00002152667,0.002550479,0.002885123,0.005626768,0.6904922,0.0005530879,0.003143817,0.2112835],"study_design_scores_gemma":[0.002712358,0.001698531,0.6590277,0.0007609286,0.0002631811,0.0007466105,0.0005329771,0.002903064,0.2489069,0.002412667,0.07947086,0.000564264],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795186,0.001425531,0.001052858,0.00970734,0.007849017,0.0002387206,0.0000102151,0.00003524702,0.0001624977],"genre_scores_gemma":[0.99489,0.0001898979,0.003284381,0.001254704,0.0003376148,0.000002586083,0.000001148967,0.0000169765,0.00002265468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5780834,"threshold_uncertainty_score":0.4403811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05315964248257915,"score_gpt":0.3758016567127963,"score_spread":0.3226420142302172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}