{"id":"W3112255487","doi":"10.1523/jneurosci.1980-20.2020","title":"Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Trace Elements in Health","field":"Nursing","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Alzheimer Society; Alzheimer's Society; Biotechnology and Biological Sciences Research Council; University of Southern California; Pfizer; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Medical Research Council; Meso Scale Diagnostics; University of Manchester; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Zinc deficiency (plant disorder); Alzheimer's disease; Microglia; Disease; Inflammation; Inflammasome; Medicine; Neuroinflammation; Cognitive decline; Zinc; Immunology; Amyloid beta; Internal medicine; Dementia; Pathology; Micronutrient; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460693,0.0003247775,0.0004014451,0.0003547651,0.0001912173,0.0003806598,0.0001863551,0.0003553765,0.001056053],"category_scores_gemma":[0.0001898705,0.0001265314,0.0003358095,0.000256787,0.0002318196,0.0002732635,0.0002254903,0.0005047664,0.0001847661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396268,"about_ca_system_score_gemma":0.0002691761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194335,"about_ca_topic_score_gemma":0.002137699,"domain_scores_codex":[0.9998938,0.00001680502,0.00001978843,0.00002429197,0.00002303709,0.00002230284],"domain_scores_gemma":[0.9998908,0.000008682739,0.00004776309,0.000008900368,0.00001847461,0.00002530662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003138911,0.0001781255,0.003521749,0.000278844,0.00007048547,0.0002105174,0.00005855974,0.00005796605,0.985626,0.00009074029,0.0001733571,0.00659473],"study_design_scores_gemma":[0.0006226083,0.007515747,0.170334,0.0001835774,0.0006538393,0.001628074,0.0003960244,0.001556381,0.8053591,0.001192114,0.0105102,0.00004830948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889122,0.008066178,0.001211532,0.000338334,0.00006276509,0.00003912303,0.0005096674,0.0001004769,0.0007597448],"genre_scores_gemma":[0.9918483,0.00480161,0.001171805,0.0001754687,0.00002026582,0.00004111839,0.0003415455,0.00001175135,0.001588173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194335,"threshold_uncertainty_score":0.003532827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05315964248257915,"score_gpt":0.3758016567127963,"score_spread":0.3226420142302172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}