{"id":"W3112272587","doi":"10.1016/j.cell.2020.11.027","title":"Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":312,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Cancer Research Society; National Science Foundation","keywords":"Chromatin; Euchromatin; Heterochromatin; Biology; Histone; Nucleosome; Scaffold/matrix attachment region; DNA; Cell biology; Biophysics; ChIA-PET; Bivalent chromatin; Histone-modifying enzymes; ChIP-sequencing; Chromatin remodeling; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008899484,0.00009270507,0.00009911544,0.00001520211,0.00002476801,0.00002076133,0.0001115165,0.00007289294,0.00001432928],"category_scores_gemma":[0.00001951114,0.00007724654,0.00002627523,0.00004336265,0.00003494105,0.000001004941,0.00009616688,0.00009012113,0.000008350587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007483172,"about_ca_system_score_gemma":0.00002143287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009784575,"about_ca_topic_score_gemma":0.0000358777,"domain_scores_codex":[0.9994415,0.00004202836,0.0001321977,0.0001977575,0.0000443262,0.000142192],"domain_scores_gemma":[0.9997435,0.00003125952,0.00003916274,0.0001359976,0.000007140938,0.00004290997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001912942,0.00003413645,0.0002492076,0.00001760052,0.00000243752,0.000003981469,0.0004166887,0.0001022144,0.9988039,0.000002370843,0.0002884901,0.00005981828],"study_design_scores_gemma":[0.0002996871,0.00009824879,0.002188951,0.00001440546,0.000003433718,0.00000122917,0.0003597203,0.006322152,0.9899278,0.00001771758,0.000647315,0.0001193436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983444,0.0001995979,0.00002042877,0.0003165884,0.00003043712,0.0001253344,0.000009454501,0.000003457198,0.0009503483],"genre_scores_gemma":[0.9984884,0.00007503127,0.0001937886,0.001006381,0.00003489015,0.000008900776,0.00001100829,0.00001340124,0.0001681496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008876128,"threshold_uncertainty_score":0.3150023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007130684540556213,"score_gpt":0.2004790172586103,"score_spread":0.1933483327180541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}