{"id":"W3112272587","doi":"10.1016/j.cell.2020.11.027","title":"Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":312,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Cancer Research Society; National Science Foundation","keywords":"Chromatin; Euchromatin; Heterochromatin; Biology; Histone; Nucleosome; Scaffold/matrix attachment region; DNA; Cell biology; Biophysics; ChIA-PET; Bivalent chromatin; Histone-modifying enzymes; ChIP-sequencing; Chromatin remodeling; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493128,0.0001258962,0.0002281209,0.0001998181,0.0003757265,0.0009134754,0.000310713,0.0004175772,0.0009213635],"category_scores_gemma":[0.0003776012,0.000261913,0.0001953973,0.0001967341,0.001377447,0.0008588048,0.0003813473,0.000707817,0.0002888498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005862595,"about_ca_system_score_gemma":0.0002416082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001702739,"about_ca_topic_score_gemma":0.002274827,"domain_scores_codex":[0.9998922,0.00001938989,0.000004670255,0.00002944826,0.00003625944,0.00001802122],"domain_scores_gemma":[0.9996587,0.0001369797,0.00004728519,0.00006981297,0.00002744458,0.00005983597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006452615,0.00001986781,0.001436322,0.00003820672,0.00001417445,0.0001291599,0.0001758418,0.004721411,0.9864255,0.005023944,0.0001248077,0.001826172],"study_design_scores_gemma":[0.00004448129,0.0001313246,0.01494124,0.00002109262,0.00002520776,0.0002801776,0.000457117,0.04115766,0.9300134,0.006337686,0.006531381,0.00005930117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760668,0.001056054,0.01905721,0.000312838,0.00007372995,0.00001178234,0.0001564289,0.0001047189,0.003160305],"genre_scores_gemma":[0.9952952,0.0003277232,0.002816486,0.00006591994,0.00001197653,0.000006064013,0.0001030501,0.00003242715,0.001341071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702739,"threshold_uncertainty_score":0.004253626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007130684540556213,"score_gpt":0.2004790172586103,"score_spread":0.1933483327180541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}