{"id":"W3112290402","doi":"10.1093/neuonc/noaa215.389","title":"EXTH-35. SYNERGISTIC EFFECT OF TARGETING THIOREDOXIN REDUCTASE (TRX1) AND DEPLETION OF GLUTATHIONE SYSTEM (GSH) IN GLIOBLASTOMA STEM CELLS","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Auranofin; Gene knockdown; Cancer research; Reactive oxygen species; Glutathione; Thioredoxin; Stem cell; Cytotoxic T cell; Apoptosis; Chemistry; Temozolomide; Thioredoxin reductase; Biology; Pharmacology; Oxidative stress; Glioma; Immunology; In vitro; Cell biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365657,0.0004407573,0.0005414263,0.0004291858,0.0001579061,0.0002718634,0.0002412705,0.0003558129,0.001460315],"category_scores_gemma":[0.0000766577,0.0001451017,0.0003807046,0.0002697527,0.0002438703,0.0001702556,0.0002957509,0.0006170936,0.0002161653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995763,"about_ca_system_score_gemma":0.0004018766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332318,"about_ca_topic_score_gemma":0.002474966,"domain_scores_codex":[0.999843,0.00002501064,0.00001598094,0.00002944642,0.00004407953,0.0000424994],"domain_scores_gemma":[0.9999261,0.000009949029,0.00001033654,0.000006442104,0.000007338627,0.00003979517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002103312,0.0007189583,0.0004635134,0.0002985322,0.00007990152,0.0002641755,0.0001152314,0.0006240684,0.9801717,0.0004614057,0.000911183,0.01378802],"study_design_scores_gemma":[0.000344679,0.006904284,0.00680721,0.00002172764,0.0001455124,0.0004037655,0.0001019066,0.00189892,0.9747654,0.0001606587,0.008426688,0.0000193619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921843,0.00290633,0.000840652,0.000221923,0.000144174,0.0001132055,0.0006415006,0.0002052924,0.002742635],"genre_scores_gemma":[0.9954364,0.0009793013,0.0009259167,0.0001029933,0.00001351233,0.00006140827,0.0006254743,0.0000104238,0.001844545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001460315,"threshold_uncertainty_score":0.004885256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007555543761766764,"score_gpt":0.2449717236720729,"score_spread":0.2374161799103061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}