{"id":"W3112291633","doi":"10.1016/j.jaccao.2020.11.004","title":"Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors","year":2020,"lang":"en","type":"article","venue":"JACC CardioOncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Children's Hospital of Eastern Ontario; University of Ottawa; McMaster Children's Hospital; London Health Sciences Centre; McMaster University; University of Toronto; SickKids Foundation; University Health Network; Université de Montréal; Hospital for Sick Children; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; C17 Children's Cancer and Blood Disorders; Hospital for Sick Children; Pediatric Oncology Group of Ontario; Ontario Institute for Cancer Research; Canadian Cancer Society","keywords":"Cardiotoxicity; Anthracycline; Medicine; Oncology; Odds ratio; Internal medicine; Ejection fraction; Doxorubicin; Cancer; Cardiology; Bioinformatics; Heart failure; Biology; Breast cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008890539,0.0002628644,0.0003546047,0.0006048826,0.0001812931,0.0004231463,0.0002368484,0.000326897,0.0004493347],"category_scores_gemma":[0.003453599,0.0001181617,0.0003981514,0.0004098071,0.0001731627,0.0001893182,0.0002710171,0.0003679396,0.00008358837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083747,"about_ca_system_score_gemma":0.0002173282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001844248,"about_ca_topic_score_gemma":0.001750772,"domain_scores_codex":[0.9996595,0.0001478514,0.00002711202,0.00007858525,0.00004894985,0.00003793099],"domain_scores_gemma":[0.9986134,0.0008663881,0.0003198419,0.00007514106,0.00007092588,0.0000542921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002310579,0.00004379374,0.9811097,0.00001127283,0.00008309275,0.00009457364,0.00002931694,0.00451296,0.001607185,0.00004242538,0.0001069361,0.01212765],"study_design_scores_gemma":[0.00002687674,0.0002159334,0.8852896,0.00001883478,0.0001282574,0.0005279838,0.0001359341,0.1109751,0.001759806,0.0006119803,0.0002975141,0.00001214646],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998181,0.0001717778,0.001403193,0.00005147425,0.000002388454,0.000004833702,0.00008785951,0.00001046537,0.00008692881],"genre_scores_gemma":[0.9988202,0.00006756717,0.0008177219,0.0000144297,0.00000446394,0.000004430755,0.0002295502,0.000002054978,0.00003953724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001844248,"threshold_uncertainty_score":0.004701793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05608322062588754,"score_gpt":0.3269253247879109,"score_spread":0.2708421041620234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}