{"id":"W3112291633","doi":"10.1016/j.jaccao.2020.11.004","title":"Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors","year":2020,"lang":"en","type":"article","venue":"JACC CardioOncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Children's Hospital of Eastern Ontario; University of Ottawa; McMaster Children's Hospital; London Health Sciences Centre; McMaster University; University of Toronto; SickKids Foundation; University Health Network; Université de Montréal; Hospital for Sick Children; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; C17 Children's Cancer and Blood Disorders; Hospital for Sick Children; Pediatric Oncology Group of Ontario; Ontario Institute for Cancer Research; Canadian Cancer Society","keywords":"Cardiotoxicity; Anthracycline; Medicine; Oncology; Odds ratio; Internal medicine; Ejection fraction; Doxorubicin; Cancer; Cardiology; Bioinformatics; Heart failure; Biology; Breast cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004060943,0.0002546225,0.001110207,0.000129175,0.00008032499,0.00002122297,0.00007546028,0.0003756341,0.0000256976],"category_scores_gemma":[0.0005329786,0.0002219886,0.000222251,0.0005004171,0.0002018544,0.00008198016,0.00005351617,0.0008133682,0.000002466074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001357698,"about_ca_system_score_gemma":0.000177693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003273436,"about_ca_topic_score_gemma":0.001475969,"domain_scores_codex":[0.9979722,0.0004342286,0.0004758894,0.0004961524,0.0002786022,0.0003429354],"domain_scores_gemma":[0.998943,0.0003881338,0.0001522072,0.0001544286,0.0001041142,0.0002581236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000172582,0.00005353327,0.9909017,0.00007641341,0.0003159474,0.0001509881,0.0005613978,0.0006561643,0.004377922,0.000001655042,0.00008699036,0.002644702],"study_design_scores_gemma":[0.003669737,0.0005480687,0.9884703,0.0000313284,0.0004166828,0.00003058679,0.0002335859,0.001032144,0.004483328,0.000008619419,0.0008275146,0.0002480738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952364,0.001905114,0.0001523998,0.001216244,0.0002915451,0.0005177098,0.00002745199,0.0001325699,0.0005205701],"genre_scores_gemma":[0.9931847,0.005329558,0.00005573275,0.0005791771,0.000671447,0.0000326574,0.0000541016,0.00004585065,0.00004671592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003497155,"threshold_uncertainty_score":0.9052433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05608322062588754,"score_gpt":0.3269253247879109,"score_spread":0.2708421041620234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}