{"id":"W3112297166","doi":"10.1093/neuonc/noaa222.510","title":"MBCL-34. EFFICACY OF METHOTREXATE (MTX) ACCORDING TO MOLECULAR SUB-TYPE IN YOUNG CHILDREN WITH MEDULLOBLASTOMA (MB): A REPORT FROM CHILDREN’S ONCOLOGY GROUP PHASE III TRIAL ACNS0334","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Medicine; Internal medicine; Medulloblastoma; Oncology; ThioTEPA; Vincristine; Etoposide; Cyclophosphamide; Chemotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004209676,0.0005335422,0.001963463,0.0004012487,0.0000735679,0.00002011166,0.0003240149,0.0004039356,0.0001017677],"category_scores_gemma":[0.001308153,0.0004516454,0.00028133,0.001039205,0.0001504222,0.0000912539,0.0002598695,0.0006597314,0.00003816182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004959166,"about_ca_system_score_gemma":0.0006348204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009700555,"about_ca_topic_score_gemma":0.0005511505,"domain_scores_codex":[0.9956693,0.0006083638,0.001240967,0.001281783,0.0005066583,0.0006929155],"domain_scores_gemma":[0.9970601,0.0007488145,0.0006815335,0.000704131,0.0001547907,0.0006506196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1070584,0.00793128,0.1480254,0.00001652802,0.001293608,0.01652329,0.001117457,0.0001210368,0.6928344,0.00004940533,0.001353975,0.02367522],"study_design_scores_gemma":[0.4443029,0.06915829,0.2099886,0.0001578004,0.002614544,0.004385444,0.0003339509,0.0001405683,0.2646669,0.00003060852,0.003408824,0.0008114047],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889502,0.0002162113,0.0001439711,0.005853163,0.0005940211,0.003545296,0.0000474254,0.000119811,0.0005298908],"genre_scores_gemma":[0.9937827,0.00006848139,0.00210063,0.002852134,0.000498404,0.0002732253,0.0003203067,0.0001022434,0.000001875813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4281675,"threshold_uncertainty_score":0.9997935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219624372525365,"score_gpt":0.3248733294773049,"score_spread":0.3029108922247684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}