{"id":"W3112297166","doi":"10.1093/neuonc/noaa222.510","title":"MBCL-34. EFFICACY OF METHOTREXATE (MTX) ACCORDING TO MOLECULAR SUB-TYPE IN YOUNG CHILDREN WITH MEDULLOBLASTOMA (MB): A REPORT FROM CHILDREN’S ONCOLOGY GROUP PHASE III TRIAL ACNS0334","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Medicine; Internal medicine; Medulloblastoma; Oncology; ThioTEPA; Vincristine; Etoposide; Cyclophosphamide; Chemotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001258855,0.0005601899,0.001122122,0.0004632975,0.0002114531,0.0005174512,0.0005061253,0.0005390856,0.001576183],"category_scores_gemma":[0.001046032,0.0002510884,0.0008809793,0.0004450107,0.0004056061,0.0003316294,0.0002222567,0.001403028,0.0002773434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001058838,"about_ca_system_score_gemma":0.0008319062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002723582,"about_ca_topic_score_gemma":0.01231345,"domain_scores_codex":[0.9995572,0.0002305382,0.00003708102,0.0000616746,0.00004829293,0.00006530558],"domain_scores_gemma":[0.9991869,0.0002146695,0.0002059821,0.00005104261,0.00003426016,0.0003071323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7202629,0.006723708,0.05524757,0.001135357,0.003017577,0.0003092969,0.000347756,0.002174115,0.02450455,0.0003185424,0.003874817,0.1820838],"study_design_scores_gemma":[0.4603581,0.3183383,0.2007001,0.0002852441,0.003421625,0.000904994,0.0001333851,0.001762207,0.006581721,0.000422549,0.007036405,0.00005523558],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990647,0.00676407,0.0001309409,0.0002824837,0.00003971071,0.0002754998,0.0008685797,0.00003248508,0.0009591533],"genre_scores_gemma":[0.9946423,0.00213745,0.0004722693,0.0002696744,0.00006409208,0.0003124485,0.001457052,0.00001222105,0.0006325511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002723582,"threshold_uncertainty_score":0.007682383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219624372525365,"score_gpt":0.3248733294773049,"score_spread":0.3029108922247684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}