{"id":"W3112306981","doi":"10.1016/j.dnarep.2020.103032","title":"DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition","year":2020,"lang":"en","type":"review","venue":"DNA repair","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acadia University","funders":"Tabriz University of Medical Sciences","keywords":"DNA damage; Autophagy; Breast cancer; Biology; DNA repair; Cancer; Cancer research; Senescence; Poly ADP ribose polymerase; Cancer cell; Apoptosis; DNA; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002683543,0.0003575484,0.001131971,0.0001617428,0.0001081726,0.00001450334,0.000101114,0.0002428714,0.0002764664],"category_scores_gemma":[0.00001876291,0.0002881287,0.0003590171,0.0004890062,0.0001251241,0.00005868653,0.00006298468,0.0002509848,0.00005240683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668527,"about_ca_system_score_gemma":0.001308877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001493702,"about_ca_topic_score_gemma":0.000003351665,"domain_scores_codex":[0.9982087,0.0001882282,0.0006228861,0.0004895938,0.0002637411,0.0002268262],"domain_scores_gemma":[0.9986902,0.0001554674,0.0003455445,0.0004912146,0.00009464183,0.0002229198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004677214,0.0002131842,0.0001169387,0.01126306,0.0009800208,0.00007605809,0.0003795434,4.866261e-8,0.0001536828,0.0001200805,0.0006570579,0.9855726],"study_design_scores_gemma":[0.000649519,0.00007229391,0.003618629,0.005719533,0.001130259,0.0001224217,0.00003744002,0.000005750655,0.000186244,0.00004483286,0.988146,0.0002670993],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004180523,0.9931889,0.00003923803,0.0003032685,0.00004057237,0.001526303,0.0002759537,0.0002130739,0.0002321349],"genre_scores_gemma":[0.001624032,0.9954538,0.0002550553,0.0003979199,0.0001605909,0.0007861398,0.0003039474,0.00007827076,0.0009401925],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9874889,"threshold_uncertainty_score":0.9999571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284329256714359,"score_gpt":0.332543183624587,"score_spread":0.3041102579531511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}