{"id":"W3112341401","doi":"10.1002/alz.040948","title":"AI‐inferred gene expression trajectories mirror neuropathology and clinical deterioration in neurodegeneration","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"","keywords":"Neuropathology; Neurodegeneration; Pathological; Disease; Population; Neuroscience; Amyloid (mycology); Alzheimer's Disease Neuroimaging Initiative; In vivo; Pathology; Medicine; Alzheimer's disease; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003843734,0.0001652106,0.0001821508,0.000027156,0.0001168625,0.0000364948,0.0001129793,0.00009163273,0.0003122043],"category_scores_gemma":[0.000085581,0.0001711826,0.00003464879,0.0001331552,0.0001501411,0.0004151735,0.0001945041,0.0002292198,0.0001525886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009049388,"about_ca_system_score_gemma":0.00001239292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009031319,"about_ca_topic_score_gemma":0.0001506998,"domain_scores_codex":[0.9978812,0.0004844753,0.0004707414,0.0006938337,0.0001973872,0.0002723217],"domain_scores_gemma":[0.9994645,0.00005335065,0.000117704,0.0001882143,0.000005137244,0.0001710706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005421524,0.00007741812,0.5301748,0.000002229737,0.00005445418,0.00004096584,0.0005097553,0.00006112772,0.4345823,0.000005214398,0.0001618396,0.03427572],"study_design_scores_gemma":[0.0006268923,0.0002409718,0.9389995,0.000004230786,0.0004001562,0.000006254337,0.00002927484,0.002525035,0.05522492,0.00004060939,0.001695794,0.0002063319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944084,0.00088753,0.002414789,0.001567656,0.0001665806,0.0003972239,0.000004421457,0.0000383529,0.0001150328],"genre_scores_gemma":[0.9905084,0.0001515947,0.003938141,0.005267724,0.00005845285,0.00002846143,0.00002290793,0.00002338244,9.631719e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4088248,"threshold_uncertainty_score":0.6980623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05171132797382231,"score_gpt":0.3083416743372043,"score_spread":0.2566303463633819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}