{"id":"W3112341401","doi":"10.1002/alz.040948","title":"AI‐inferred gene expression trajectories mirror neuropathology and clinical deterioration in neurodegeneration","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"","keywords":"Neuropathology; Neurodegeneration; Pathological; Disease; Population; Neuroscience; Amyloid (mycology); Alzheimer's Disease Neuroimaging Initiative; In vivo; Pathology; Medicine; Alzheimer's disease; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000387364,0.0003682204,0.0002609902,0.0007020737,0.0001467434,0.0004926163,0.0002796713,0.0003200394,0.001214846],"category_scores_gemma":[0.001322602,0.0001125354,0.0003265092,0.0005090078,0.0002364422,0.0002419473,0.0002561422,0.0003794806,0.0003856113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003823327,"about_ca_system_score_gemma":0.000365356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003802899,"about_ca_topic_score_gemma":0.003822157,"domain_scores_codex":[0.9998513,0.00002301189,0.000007193156,0.00008229195,0.00001761536,0.00001851422],"domain_scores_gemma":[0.9996158,0.0001596531,0.00008070913,0.00003940815,0.00007466952,0.00002972086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001902838,0.0002276167,0.6252034,0.0002517551,0.0004813993,0.000297163,0.0002690477,0.07853301,0.1631396,0.001389223,0.002268722,0.1260362],"study_design_scores_gemma":[0.00003264218,0.0002242868,0.467337,0.00005529718,0.0001662283,0.0005834993,0.0001634139,0.4818077,0.04291924,0.004516983,0.0021406,0.0000530738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9228221,0.0005359287,0.06928493,0.0001426527,0.00001738521,0.00003770855,0.005599123,0.0006808224,0.0008793288],"genre_scores_gemma":[0.9763071,0.0001828252,0.01904597,0.00004412507,0.00001310475,0.00004439339,0.003822289,0.00004220378,0.0004980321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003802899,"threshold_uncertainty_score":0.007561505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05171132797382231,"score_gpt":0.3083416743372043,"score_spread":0.2566303463633819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}