{"id":"W3112356895","doi":"10.1126/scitranslmed.aaz7423","title":"Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy","year":2020,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"GENSIGHT BIOLOGICS PARIS; Medical Research Council; Ministero della Salute; E-Rare; Agence Nationale de la Recherche; Sight Research UK; Moorfields Eye Hospital NHS Foundation Trust; Bundesministerium für Bildung und Forschung; Isaac Newton Trust; National Institute for Health and Care Research","keywords":"Genetic enhancement; Optic neuropathy; Medicine; Leber's hereditary optic neuropathy; Ophthalmology; Optic nerve; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957588,0.0003158642,0.0003368079,0.0003263683,0.0001836788,0.0001542017,0.00009538999,0.000271587,0.00294155],"category_scores_gemma":[0.000275197,0.00009387131,0.0001446906,0.0001669835,0.0002672384,0.0002391661,0.0001656054,0.0002951208,0.0003346727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245253,"about_ca_system_score_gemma":0.0002131221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131277,"about_ca_topic_score_gemma":0.001662055,"domain_scores_codex":[0.99985,0.00003536862,0.000007515498,0.00002598304,0.00005120827,0.00002977317],"domain_scores_gemma":[0.9999259,0.00001829196,0.00001572944,0.000009316115,0.000004941102,0.00002586897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005180137,0.003156541,0.008199927,0.0002110981,0.00008239566,0.002918029,0.0002018371,0.00048879,0.8926522,0.0004375395,0.001654605,0.0848169],"study_design_scores_gemma":[0.003380607,0.1725083,0.2687978,0.0001151102,0.0003407741,0.04588377,0.0003137652,0.01002908,0.4821783,0.001076108,0.01524035,0.0001360485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938927,0.0007395924,0.001313397,0.0001316535,0.00004075909,0.00007311666,0.00007126234,0.0001695556,0.003567932],"genre_scores_gemma":[0.9971538,0.0002445251,0.0006001374,0.0000585312,0.00001345508,0.00004450709,0.00007939583,0.00001161637,0.001794041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00294155,"threshold_uncertainty_score":0.009840488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577718739012107,"score_gpt":0.2666228530061965,"score_spread":0.2508456656160754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}