{"id":"W3112356895","doi":"10.1126/scitranslmed.aaz7423","title":"Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy","year":2020,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"GENSIGHT BIOLOGICS PARIS; Medical Research Council; Ministero della Salute; E-Rare; Agence Nationale de la Recherche; Sight Research UK; Moorfields Eye Hospital NHS Foundation Trust; Bundesministerium für Bildung und Forschung; Isaac Newton Trust; National Institute for Health and Care Research","keywords":"Genetic enhancement; Optic neuropathy; Medicine; Leber's hereditary optic neuropathy; Ophthalmology; Optic nerve; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001700484,0.0001156767,0.00008918498,0.00004586528,0.000131282,0.00001397488,0.0001231099,0.00002495282,0.00002608489],"category_scores_gemma":[0.00001932491,0.00007950114,0.00002571171,0.0002281508,0.0002926701,0.00001706161,0.00001036976,0.00004305088,0.000001488543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005728215,"about_ca_system_score_gemma":0.0001629844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000837867,"about_ca_topic_score_gemma":0.000004120714,"domain_scores_codex":[0.9990109,0.00001034393,0.0001537624,0.0003334142,0.0003025475,0.0001889961],"domain_scores_gemma":[0.9996706,0.000007809559,0.00003760842,0.00006264334,0.0001145752,0.0001067458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000708379,0.00002726144,0.004892183,0.00001127061,0.00001456023,0.000002977936,0.0003854612,0.0005562111,0.9865921,0.00006316671,0.0001048572,0.006641577],"study_design_scores_gemma":[0.01963245,0.04492199,0.2446035,0.000100753,0.00008903218,0.0001793762,0.000963069,0.01990803,0.6449235,0.001248842,0.02188277,0.001546676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845027,0.0001278325,0.009412844,0.005177632,0.0001787035,0.0003359474,0.000004378414,0.00001244098,0.0002475776],"genre_scores_gemma":[0.995786,0.00002189436,0.001913012,0.001688453,0.0003733785,0.00002377916,0.0001316781,0.0000105523,0.00005128148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3416686,"threshold_uncertainty_score":0.3241962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577718739012107,"score_gpt":0.2666228530061965,"score_spread":0.2508456656160754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}