{"id":"W3112369087","doi":"10.1186/s13148-020-00988-1","title":"High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations","year":2020,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; National Research Council Canada; McGill University and Génome Québec Innovation Centre; McGill University","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"DNA methylation; CpG site; Epigenome; Biology; Methylation; Epigenetics; Differentially methylated regions; Human genetics; Sperm; Genetics; Andrology; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006653049,0.0002777464,0.0006912735,0.00008835486,0.00009819384,0.00001689193,0.0003839819,0.0004607364,0.00004172638],"category_scores_gemma":[0.0008266973,0.0002780792,0.0004309106,0.000370178,0.0004719051,0.000004862373,0.000198081,0.0002395636,0.000005420869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001303876,"about_ca_system_score_gemma":0.0001276823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005141738,"about_ca_topic_score_gemma":0.00004478078,"domain_scores_codex":[0.9965132,0.0002986322,0.001960317,0.0006189579,0.0003098546,0.0002990139],"domain_scores_gemma":[0.9978989,0.000144557,0.0007313302,0.0006416551,0.0003311728,0.0002523722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005667065,0.0003623882,0.004300934,0.00005652993,0.0002107392,0.000001934775,0.00007273282,0.01665634,0.9760159,0.0002285905,0.00005266422,0.001984567],"study_design_scores_gemma":[0.002275841,0.003236602,0.07112939,0.00004714503,0.000399997,9.507219e-7,0.00004061597,0.007592929,0.9130659,0.001194793,0.0005487539,0.0004670784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389582,0.002983556,0.05688371,0.0002376436,0.000246515,0.0003039505,0.0001266114,0.00001707636,0.0002427158],"genre_scores_gemma":[0.9823263,0.001704517,0.01493934,0.0001133898,0.0002408791,0.000008533556,0.0004738279,0.00005005969,0.0001431284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06682846,"threshold_uncertainty_score":0.9999672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1095152211219206,"score_gpt":0.4189905006740487,"score_spread":0.3094752795521282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}