{"id":"W3112388253","doi":"10.3390/vaccines9020097","title":"An Update on Self-Amplifying mRNA Vaccine Development","year":2021,"lang":"en","type":"review","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada); Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"H2020 Marie Skłodowska-Curie Actions","keywords":"Computational biology; Vector (molecular biology); Virology; Biology; Computer science; Medicine; Immunology; Genetics; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001486423,0.0004970476,0.0008660131,0.0001223405,0.0001046046,0.00006897235,0.0004815275,0.0003772315,0.00009544956],"category_scores_gemma":[0.000043128,0.0003988749,0.0002841169,0.0001545451,0.000003077482,0.00000336744,0.0001737199,0.0001889214,0.0001769823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003334791,"about_ca_system_score_gemma":0.0003590659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004753955,"about_ca_topic_score_gemma":0.00002687294,"domain_scores_codex":[0.9981564,0.0001110806,0.0005104056,0.0007691527,0.0001263909,0.0003266122],"domain_scores_gemma":[0.9987263,0.00001349377,0.0002063859,0.0007690323,0.0001633661,0.000121395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001862279,0.0001702562,0.00002814794,0.00168839,0.0005025071,0.00002483678,0.00001826129,0.000003859903,0.0002302874,0.00002327859,0.01422568,0.9830658],"study_design_scores_gemma":[0.0001562337,0.0001715552,0.00001529209,0.001817078,0.0001666173,0.00002995,0.00001096192,0.000001172973,0.002238687,0.000002007331,0.994908,0.000482466],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001957492,0.996806,0.00004053255,0.00001241231,0.0005328259,0.0002529014,0.000017724,0.00004050642,0.0003396532],"genre_scores_gemma":[0.0002181047,0.9952201,0.0009188459,0.0002489795,0.001041219,0.00008043741,0.001712655,0.00007295545,0.0004866908],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9825834,"threshold_uncertainty_score":0.9998463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336755002198036,"score_gpt":0.3309065007306801,"score_spread":0.2975389507086997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}