{"id":"W3112388253","doi":"10.3390/vaccines9020097","title":"An Update on Self-Amplifying mRNA Vaccine Development","year":2021,"lang":"en","type":"review","venue":"Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada); Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"H2020 Marie Skłodowska-Curie Actions","keywords":"Computational biology; Vector (molecular biology); Virology; Biology; Computer science; Medicine; Immunology; Genetics; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006024106,0.0007046188,0.0009233601,0.001592413,0.0002057585,0.0008336608,0.0006858772,0.0008941495,0.006214568],"category_scores_gemma":[0.0007369712,0.0003509597,0.000420648,0.00130641,0.0002914165,0.001189835,0.0004771781,0.001892395,0.004465167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004515847,"about_ca_system_score_gemma":0.0009151027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005706325,"about_ca_topic_score_gemma":0.001058408,"domain_scores_codex":[0.9998005,0.00003238242,0.00003261185,0.00003116915,0.00008099565,0.00002228432],"domain_scores_gemma":[0.9996855,0.0001744635,0.00003411706,0.000008377585,0.00007393683,0.00002363688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006884309,0.00007019172,0.00009303913,0.01523905,0.00005545224,0.0002287402,0.00004805962,0.0002868832,0.005243588,0.003119208,0.0499433,0.9256036],"study_design_scores_gemma":[0.000007575543,0.00007234685,0.0001505233,0.001145536,0.00004351183,0.0006193401,0.00001144133,0.00003446593,0.0007922632,0.0004701188,0.996644,0.000008983088],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000194565,0.9950819,0.0005937294,0.0004666036,0.001034878,0.0000153082,0.00006414072,0.00002765156,0.002521206],"genre_scores_gemma":[0.0005983149,0.9956841,0.0006154166,0.0005866238,0.0004351368,0.00001869708,0.0001085954,0.000006608159,0.001946381],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006214568,"threshold_uncertainty_score":0.02078974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336755002198036,"score_gpt":0.3309065007306801,"score_spread":0.2975389507086997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}