{"id":"W3112414503","doi":"10.1016/j.mad.2020.111414","title":"The ULK1 kinase, a necessary component of the pro-regenerative and anti-aging machinery in Hydra","year":2020,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Marine Invertebrate Physiology and Ecology","field":"Earth and Planetary Sciences","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics and Genomics of Geneva; Institute of Genetics; Canton de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Autophagy; ULK1; Cell biology; Lernaean Hydra; Biology; Autophagosome; Senescence; Stem cell; Kinase; Regeneration (biology); Homeostasis; Protein kinase A; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413578,0.00008272545,0.0001589879,0.0000217296,0.0001964158,0.00001009717,0.000114437,0.000031724,0.00003424805],"category_scores_gemma":[0.00002157933,0.00004611713,0.00001286278,0.00008183048,0.00008736312,0.00003996615,0.00007397879,0.00009932517,0.00000155279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001599888,"about_ca_system_score_gemma":0.00004519361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004503859,"about_ca_topic_score_gemma":0.001241083,"domain_scores_codex":[0.9993488,0.00009080071,0.0002004472,0.0001454585,0.00007951854,0.0001349853],"domain_scores_gemma":[0.9997088,0.00009748038,0.00008525598,0.00005940815,0.00001206992,0.00003695047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002037999,0.00007606106,0.8452254,0.0003829055,0.0001614355,0.00005500799,0.009439353,0.004750466,0.04425736,0.004910463,0.0002876172,0.09025014],"study_design_scores_gemma":[0.0002745166,0.00006776477,0.9558246,0.00003441114,0.000004987601,0.000004299196,0.0004611501,0.01129248,0.02900376,0.002705134,0.0002295757,0.00009737638],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975962,0.0003033756,0.0002437392,0.001363633,0.00008906781,0.0001257226,0.000003356347,0.000005404509,0.0002695051],"genre_scores_gemma":[0.998563,0.00005573988,0.0009494286,0.0003962888,0.000009328186,0.000001710803,0.000007514603,0.000001483688,0.00001550223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1105992,"threshold_uncertainty_score":0.1880602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488914288793977,"score_gpt":0.1934399420612288,"score_spread":0.178550799173289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}