{"id":"W3112416841","doi":"10.1093/neuonc/noaa222.307","title":"HGG-20. DIAGNOSTIC AND BIOLOGICAL ROLE OF METHYLATION PATTERNS IN REPLICATION REPAIR DEFICIENT HIGH GRADE GLIOMAS","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Princess Margaret Cancer Centre; Dalhousie University; Université Laval; Hospital for Sick Children","funders":"","keywords":"Epigenetics; DNA methylation; Methylation; Biology; Genetics; Context (archaeology); Gene; Cancer research; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272953,0.0001633326,0.0001476445,0.0005294298,0.00008812711,0.0002506669,0.0001328814,0.0001994944,0.000932791],"category_scores_gemma":[0.0002011664,0.0001104349,0.00009472257,0.0002475853,0.0001389634,0.00007695191,0.0001822491,0.0001410226,0.0002210599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206135,"about_ca_system_score_gemma":0.00008242828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409833,"about_ca_topic_score_gemma":0.001988055,"domain_scores_codex":[0.9998459,0.00002163605,0.00001173085,0.00004458837,0.00003944457,0.00003675435],"domain_scores_gemma":[0.9998523,0.00001914825,0.00005206329,0.00001669312,0.00002102468,0.00003878132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002517014,0.000007378778,0.02831506,0.00002718499,0.00001592119,0.00008329706,0.00002531951,0.00007635565,0.968298,0.00003696412,0.00003465401,0.002828054],"study_design_scores_gemma":[0.000006707859,0.0002991546,0.6019327,0.000005031453,0.00004626935,0.001713556,0.0001092721,0.001366091,0.3932981,0.000103514,0.001112557,0.000006920096],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972649,0.0003235235,0.001319367,0.0000152741,0.000002014993,0.000009038118,0.0004765815,0.00006336649,0.0005258808],"genre_scores_gemma":[0.9978455,0.00008058726,0.001244123,0.00001033878,0.000001202969,0.000005979842,0.0004656002,0.00001008326,0.000336638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409833,"threshold_uncertainty_score":0.003120482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02479956331006021,"score_gpt":0.2849263233552051,"score_spread":0.2601267600451449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}