{"id":"W3112419967","doi":"10.1038/s41590-020-00845-6","title":"Trained immunity, tolerance, priming and differentiation: distinct immunological processes","year":2020,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":595,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Quillen College of Medicine, East Tennessee State University; Weill Cornell Medical College; Universitätsklinikum Jena; Rheinische Friedrich-Wilhelms-Universität Bonn; Syddansk Universitet; Deutsches Zentrum für Neurodegenerative Erkrankungen; Centre National de la Recherche Scientifique; Radboud Universiteit; Trinity College Dublin; Radboud Universitair Medisch Centrum; Vanderbilt University Medical Center; Technische Universiteit Eindhoven; University of Melbourne; Memorial Sloan-Kettering Cancer Center; Murdoch Children's Research Institute; Broad Institute; Zentrum für Regenerative Therapien Dresden; Children’s Hospital of Wisconsin Research Institute; Klinisk Institut, Syddansk Universitet; National Institutes of Health; McGill University Health Centre; Texas Children's Hospital; McGill University; Washington University in St. Louis; Massachusetts Institute of Technology; Technische Universität Dresden; Massachusetts General Hospital; Institut National de la Santé et de la Recherche Médicale; Vanderbilt University; Odense Universitetshospital; East Tennessee State University","keywords":"Immunity; Priming (agriculture); Immunology; Immune system; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001420569,0.0003328049,0.0005142083,0.0001271105,0.0005476701,0.00004681198,0.0004592027,0.001013051,0.0006881618],"category_scores_gemma":[0.001162412,0.000279132,0.0001013464,0.0004362412,0.0003288124,0.0002211865,0.0003329474,0.001692255,0.0001418688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003310707,"about_ca_system_score_gemma":0.0001161867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001658336,"about_ca_topic_score_gemma":0.000009437656,"domain_scores_codex":[0.9981866,0.0003514818,0.000430223,0.0004761638,0.00004982012,0.000505726],"domain_scores_gemma":[0.9987759,0.0004840341,0.0001912793,0.0003059726,0.0002099704,0.00003284802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003862614,0.0005202652,0.005461276,0.0002400004,0.001150706,0.00003370862,0.003608882,0.000003527329,0.9072328,0.01709052,0.001474864,0.05932088],"study_design_scores_gemma":[0.009717698,0.002315301,0.6124289,0.0001343799,0.0002897124,0.0008369597,0.001757946,0.00005220731,0.09287705,0.001294783,0.2769411,0.001353991],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9090154,0.08144798,0.0005376852,0.006384924,0.0007343921,0.0003956401,0.00004630386,0.0003166955,0.001120946],"genre_scores_gemma":[0.9971364,0.001041089,0.0001268874,0.0007347972,0.00006834274,0.00004854015,0.0002473999,0.00002782073,0.0005687578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8143557,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401180088500188,"score_gpt":0.2521851492973577,"score_spread":0.2381733484123559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}