{"id":"W3112419967","doi":"10.1038/s41590-020-00845-6","title":"Trained immunity, tolerance, priming and differentiation: distinct immunological processes","year":2020,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":595,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Quillen College of Medicine, East Tennessee State University; Weill Cornell Medical College; Universitätsklinikum Jena; Rheinische Friedrich-Wilhelms-Universität Bonn; Syddansk Universitet; Deutsches Zentrum für Neurodegenerative Erkrankungen; Centre National de la Recherche Scientifique; Radboud Universiteit; Trinity College Dublin; Radboud Universitair Medisch Centrum; Vanderbilt University Medical Center; Technische Universiteit Eindhoven; University of Melbourne; Memorial Sloan-Kettering Cancer Center; Murdoch Children's Research Institute; Broad Institute; Zentrum für Regenerative Therapien Dresden; Children’s Hospital of Wisconsin Research Institute; Klinisk Institut, Syddansk Universitet; National Institutes of Health; McGill University Health Centre; Texas Children's Hospital; McGill University; Washington University in St. Louis; Massachusetts Institute of Technology; Technische Universität Dresden; Massachusetts General Hospital; Institut National de la Santé et de la Recherche Médicale; Vanderbilt University; Odense Universitetshospital; East Tennessee State University","keywords":"Immunity; Priming (agriculture); Immunology; Immune system; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001167363,0.000511507,0.001113522,0.0005634543,0.0004240781,0.00196242,0.0008132663,0.001362,0.002022662],"category_scores_gemma":[0.001406807,0.0003867801,0.0004445109,0.0002628799,0.001296041,0.001890006,0.00107315,0.002412887,0.0004691913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004855703,"about_ca_system_score_gemma":0.0005849341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001999117,"about_ca_topic_score_gemma":0.0003442593,"domain_scores_codex":[0.9993219,0.000153471,0.0000508374,0.0001334365,0.0001429252,0.0001973957],"domain_scores_gemma":[0.9991067,0.000262133,0.0001401929,0.0001657298,0.00009248617,0.0002327272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002547316,0.0008314561,0.01019431,0.0009452745,0.00007457138,0.0004060754,0.001649942,0.001372376,0.8082352,0.05347071,0.0007543796,0.1195184],"study_design_scores_gemma":[0.0005582054,0.01487132,0.3788839,0.001604429,0.0004789232,0.003203633,0.004538682,0.01726914,0.3870258,0.1633604,0.02786863,0.0003369343],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605758,0.01268987,0.01416769,0.0007137459,0.0003966751,0.0001495781,0.0001439445,0.0001442143,0.01101845],"genre_scores_gemma":[0.9873496,0.00325177,0.004638589,0.0002936614,0.0001789063,0.0001311455,0.0001449128,0.00004873026,0.003962674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022662,"threshold_uncertainty_score":0.006766438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401180088500188,"score_gpt":0.2521851492973577,"score_spread":0.2381733484123559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}