{"id":"W3112448433","doi":"10.1183/13993003.02774-2020","title":"Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator","year":2020,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; Ontario Genomics Institute; Government of Canada; Government of Ontario; Sick Kids Foundation; Genome Canada; Ontario Genomics; Cystic Fibrosis Canada","keywords":"Ivacaftor; Potentiator; Medicine; Cystic fibrosis; Mutation; Mutant; Cystic fibrosis transmembrane conductance regulator; Pharmacology; Genetics; Gene; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815669,0.0003618195,0.0006194049,0.0001691356,0.000132607,0.0003041545,0.0002883229,0.0003052814,0.001795493],"category_scores_gemma":[0.0001837609,0.0001287641,0.0005412519,0.0001285227,0.0001651133,0.0001792902,0.0002996118,0.0007121928,0.0004438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373903,"about_ca_system_score_gemma":0.0002880913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005926114,"about_ca_topic_score_gemma":0.0008461992,"domain_scores_codex":[0.9998025,0.00003367365,0.00002722308,0.00003059548,0.00005155993,0.00005441427],"domain_scores_gemma":[0.9998691,0.00002394229,0.00002669646,0.00003116769,0.00001569133,0.00003332729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004985104,0.0001092945,0.0002684536,0.00003275915,0.00001083917,0.0001092483,0.00001678973,0.00007807834,0.9951558,0.00004710026,0.00007696114,0.003596265],"study_design_scores_gemma":[0.0001815794,0.004137825,0.005101996,0.00001093101,0.00004102345,0.0008549945,0.00004688177,0.0007749887,0.9860774,0.00002573921,0.00274047,0.000006075152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971429,0.0006956562,0.0008448758,0.00008368116,0.00004072682,0.00004621471,0.000225761,0.00005460619,0.0008656405],"genre_scores_gemma":[0.995165,0.0006258868,0.001513073,0.0000433295,0.00001801759,0.00003439998,0.000455589,0.0000213374,0.002123274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795493,"threshold_uncertainty_score":0.006006539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377640362065698,"score_gpt":0.2782026220927991,"score_spread":0.2544262184721421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}