{"id":"W3112472197","doi":"10.4049/jimmunol.2000382","title":"<i>Salmonella</i> Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Wellcome Trust; GlaxoSmithKline","keywords":"Flagellin; NLRC4; Salmonella; Non canonical; Microbiology; Biology; Chemistry; Inflammasome; Cell biology; Inflammation; Bacteria; Immunology; Genetics; Caspase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037148,0.0002816439,0.0002319359,0.0001940956,0.0001521132,0.0002668175,0.0001051813,0.0002960361,0.001090945],"category_scores_gemma":[0.0001957635,0.0001463874,0.0004675562,0.0001379992,0.0001839687,0.000160355,0.0002403132,0.0003046821,0.0005069562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002731835,"about_ca_system_score_gemma":0.0002145608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008136193,"about_ca_topic_score_gemma":0.0005324924,"domain_scores_codex":[0.9997138,0.00007444347,0.00004127698,0.00003626279,0.00005285099,0.00008146199],"domain_scores_gemma":[0.999912,0.00001108992,0.00002565195,0.00001537861,0.00001939124,0.0000164114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006172105,0.00003101669,0.0009140192,0.00008969672,0.00001152262,0.0001720649,0.00003515433,0.00003497252,0.996976,0.00004157655,0.0001477169,0.0009291145],"study_design_scores_gemma":[0.000216659,0.001455099,0.06817581,0.00003407739,0.00007096605,0.003033221,0.0002970049,0.001596266,0.9179505,0.0001606332,0.006992355,0.00001733975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915916,0.00340121,0.002607142,0.0002970361,0.00006494227,0.0000669009,0.000561087,0.00007647918,0.001333751],"genre_scores_gemma":[0.9965245,0.000700747,0.0009903339,0.0001566778,0.00002979653,0.00006488887,0.0007311755,0.000008338776,0.0007935126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090945,"threshold_uncertainty_score":0.003649592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00750565874207714,"score_gpt":0.2266932487265998,"score_spread":0.2191875899845226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}