{"id":"W3112472197","doi":"10.4049/jimmunol.2000382","title":"<i>Salmonella</i> Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Wellcome Trust; GlaxoSmithKline","keywords":"Flagellin; NLRC4; Salmonella; Non canonical; Microbiology; Biology; Chemistry; Inflammasome; Cell biology; Inflammation; Bacteria; Immunology; Genetics; Caspase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003218538,0.0001519219,0.000261987,0.00005269099,0.00008816789,0.00001571334,0.0003614533,0.0001545753,0.00002595075],"category_scores_gemma":[0.0001191476,0.0001085769,0.00007923421,0.00009701887,0.0002561729,0.00001041254,0.0001729876,0.0003795136,0.000005000421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009999711,"about_ca_system_score_gemma":0.00007515109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003005288,"about_ca_topic_score_gemma":0.0000232134,"domain_scores_codex":[0.9989037,0.0002185239,0.0004249272,0.0001258827,0.00008302166,0.0002439713],"domain_scores_gemma":[0.9994326,0.00004572246,0.0002348549,0.0001747367,0.00006811288,0.00004402056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005298168,0.00002756039,0.001834396,0.000009216495,0.0001218491,0.00002185352,0.0005709815,0.00007561425,0.9950064,0.00003582057,0.0004224743,0.001343992],"study_design_scores_gemma":[0.001735838,0.001167618,0.01117337,0.00001987467,0.00003648288,0.0001844561,0.001039028,0.000008733738,0.9670284,0.0001665213,0.01726524,0.0001744523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843932,0.01303082,0.00003125278,0.002048089,0.00008500275,0.00008184146,0.000001523109,0.000003575806,0.0003246602],"genre_scores_gemma":[0.9944714,0.004677812,0.00004449959,0.0005265893,0.0001428628,0.000001568704,0.000005223932,0.00001806467,0.0001119224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02797805,"threshold_uncertainty_score":0.4427638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00750565874207714,"score_gpt":0.2266932487265998,"score_spread":0.2191875899845226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}