{"id":"W3112477377","doi":"10.1002/alz.044198","title":"Pre‐clinical development of a blood‐brain barrier (BBB)‐penetrating anti‐amyloid‒β fusion protein","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"In vivo; Blood–brain barrier; In vitro; Microglia; Parenchyma; Cytokine; Western blot; Pharmacology; Chemistry; Fusion protein; Molecular biology; Biology; Cell biology; Recombinant DNA; Pathology; Immunology; Biochemistry; Inflammation; Medicine; Central nervous system; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000480984,0.0003553048,0.0003309115,0.000229591,0.0001667722,0.0004942655,0.0003412986,0.0004345564,0.001762157],"category_scores_gemma":[0.0002260181,0.00009334279,0.0002516192,0.0001436745,0.0002693058,0.0002865201,0.0002296098,0.000660529,0.0007682673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003570908,"about_ca_system_score_gemma":0.0004735066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004774389,"about_ca_topic_score_gemma":0.0006279444,"domain_scores_codex":[0.9998438,0.00003603816,0.00001015009,0.00002001927,0.00005276509,0.00003718409],"domain_scores_gemma":[0.9998553,0.0000188888,0.00002605968,0.00001082937,0.00004580054,0.00004311554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001074402,0.00178025,0.001329509,0.0005482348,0.0000446067,0.0006384349,0.0001043694,0.0004034588,0.9283644,0.0007109477,0.001697336,0.06330404],"study_design_scores_gemma":[0.0009193455,0.04551021,0.01791883,0.0001572698,0.0002400192,0.006089068,0.0001537666,0.002201478,0.8612893,0.0005054455,0.06498949,0.0000257887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456285,0.01634119,0.02457055,0.001259242,0.0002399204,0.001178048,0.0006509139,0.00039886,0.009732802],"genre_scores_gemma":[0.9684228,0.01027192,0.01478994,0.0005268886,0.0001084986,0.0004011239,0.001429375,0.00005208955,0.003997436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762157,"threshold_uncertainty_score":0.005894959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05729834459728859,"score_gpt":0.3419874309969596,"score_spread":0.284689086399671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}