{"id":"W3112498330","doi":"10.1016/j.kint.2020.10.042","title":"Insights from CREDENCE trial indicate an acute drop in estimated glomerular filtration rate during treatment with canagliflozin with implications for clinical practice","year":2020,"lang":"en","type":"article","venue":"Kidney International","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of British Columbia","funders":"Janssen Research and Development; University of California, San Francisco; Astellas Pharma; Eisai; Celgene; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Medical Research Council; Verily Life Sciences; National Health and Medical Research Council; AstraZeneca; Amarin Corporation; National Institutes of Health; Regeneron Pharmaceuticals; Pfizer; Innovent Biologics; Janssen Pharmaceuticals; Ablynx; University of Washington; Ironwood Pharmaceuticals, Incorporated; Relypsa; University of Chicago; Alnylam Pharmaceuticals; Novo Nordisk; MyoKardia; Daiichi Sankyo Europe; Servier; Gilead Sciences; Kidney Foundation of Canada; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Japan Society for the Promotion of Science; GlaxoSmithKline; Amgen; Eli Lilly and Company; Akebia Therapeutics; Bristol-Myers Squibb","keywords":"Canagliflozin; Medicine; Renal function; Placebo; Kidney disease; Internal medicine; Post-hoc analysis; Confidence interval; Odds ratio; Proportional hazards model; Diabetes mellitus; Type 2 diabetes; Urology; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007171414,0.0001828094,0.0002686893,0.0001044422,0.00006716295,0.000070448,0.0001303069,0.00005775209,0.0000465343],"category_scores_gemma":[0.0002639664,0.0001325852,0.00005327121,0.0001808463,0.00004912422,0.0004246989,0.00002237543,0.00009388606,0.00001492847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002341986,"about_ca_system_score_gemma":0.0003136133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002804764,"about_ca_topic_score_gemma":0.0001546125,"domain_scores_codex":[0.9987289,0.00005873891,0.0003808691,0.0004603697,0.0002135963,0.0001574858],"domain_scores_gemma":[0.9989491,0.0001289497,0.0002187721,0.0002086701,0.000156605,0.0003378656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4712641,0.01989313,0.3698532,0.0001692641,0.03130116,0.001686323,0.007223501,0.0007926554,0.04550625,0.01553527,0.01086462,0.02591045],"study_design_scores_gemma":[0.3071456,0.02714751,0.5613014,0.0004628958,0.005107872,0.00002917303,0.0004916152,0.02052099,0.006375652,0.0004830587,0.07005752,0.0008767335],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588305,0.00003414454,0.00220607,0.03540187,0.0001498458,0.001911173,0.0002577058,0.00009008741,0.0011186],"genre_scores_gemma":[0.9728879,0.0001220552,0.01972522,0.002601891,0.0003598401,0.0006772617,0.003372551,0.00002857498,0.000224718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1914481,"threshold_uncertainty_score":0.5406669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07070988077867671,"score_gpt":0.3826424693149185,"score_spread":0.3119325885362417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}