{"id":"W3112498330","doi":"10.1016/j.kint.2020.10.042","title":"Insights from CREDENCE trial indicate an acute drop in estimated glomerular filtration rate during treatment with canagliflozin with implications for clinical practice","year":2020,"lang":"en","type":"article","venue":"Kidney International","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of British Columbia","funders":"Janssen Research and Development; University of California, San Francisco; Astellas Pharma; Eisai; Celgene; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Medical Research Council; Verily Life Sciences; National Health and Medical Research Council; AstraZeneca; Amarin Corporation; National Institutes of Health; Regeneron Pharmaceuticals; Pfizer; Innovent Biologics; Janssen Pharmaceuticals; Ablynx; University of Washington; Ironwood Pharmaceuticals, Incorporated; Relypsa; University of Chicago; Alnylam Pharmaceuticals; Novo Nordisk; MyoKardia; Daiichi Sankyo Europe; Servier; Gilead Sciences; Kidney Foundation of Canada; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Japan Society for the Promotion of Science; GlaxoSmithKline; Amgen; Eli Lilly and Company; Akebia Therapeutics; Bristol-Myers Squibb","keywords":"Canagliflozin; Medicine; Renal function; Placebo; Kidney disease; Internal medicine; Post-hoc analysis; Confidence interval; Odds ratio; Proportional hazards model; Diabetes mellitus; Type 2 diabetes; Urology; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02368249,0.0004512682,0.001488028,0.0003284994,0.0003729231,0.001815574,0.0005061923,0.001221037,0.005298459],"category_scores_gemma":[0.0465547,0.0001773072,0.002022269,0.0007035033,0.0005741762,0.001419968,0.0006452294,0.001855841,0.0005693587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004921833,"about_ca_system_score_gemma":0.001169207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009698535,"about_ca_topic_score_gemma":0.001989244,"domain_scores_codex":[0.9879313,0.007517913,0.000827127,0.0009926073,0.002149749,0.0005812632],"domain_scores_gemma":[0.9476569,0.03457969,0.01019364,0.00332714,0.00238077,0.001861862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1759618,0.002025978,0.5582561,0.001976678,0.006981186,0.0007031787,0.0007372061,0.002036777,0.002645811,0.004977516,0.02647793,0.2172198],"study_design_scores_gemma":[0.01649741,0.01964646,0.9110425,0.0006526278,0.006601911,0.001281166,0.000486793,0.007697077,0.001319407,0.008504816,0.02611845,0.0001514077],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9338486,0.01647782,0.005687382,0.01283354,0.0009485856,0.0005947453,0.005055831,0.0001577259,0.02439576],"genre_scores_gemma":[0.9891706,0.001047263,0.001667005,0.003759946,0.0005547283,0.0001614965,0.002304102,0.00002998082,0.001304933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02368249,"threshold_uncertainty_score":0.1252465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07070988077867671,"score_gpt":0.3826424693149185,"score_spread":0.3119325885362417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}