{"id":"W3112504169","doi":"10.1016/j.stem.2020.11.013","title":"Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells","year":2020,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Rosetrees Trust","keywords":"Induced pluripotent stem cell; Biology; Embryonic stem cell; Carcinogenesis; Stem cell; Genetics; Molecular biology; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002940934,0.0008743649,0.0008414068,0.000353549,0.0002465729,0.0001784024,0.001386657,0.001657223,0.0002144548],"category_scores_gemma":[0.000002970663,0.0009523184,0.0004751211,0.0005024658,0.000171307,0.00001132635,0.0006391191,0.002287134,0.0007113211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003365847,"about_ca_system_score_gemma":0.0005519362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002182007,"about_ca_topic_score_gemma":0.00007505038,"domain_scores_codex":[0.9941517,0.0005884778,0.001194964,0.001880468,0.0009164705,0.001267979],"domain_scores_gemma":[0.9976099,0.00006551312,0.0005876035,0.001222227,0.0002109959,0.0003037702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000215366,0.0001371768,0.00005832922,0.0009447245,0.0001024808,0.0007186307,0.0001893081,0.0002198647,0.6154086,4.882692e-7,0.3820273,0.0001715],"study_design_scores_gemma":[0.001220599,0.0001531773,0.00002416022,0.00008848951,0.00009956647,0.000005361185,0.00007833002,0.0001066655,0.5817397,0.00001076045,0.4157495,0.0007236515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7737929,0.02266671,0.0002409192,0.1354184,0.006257238,0.01139095,0.001716038,0.0006369671,0.04787998],"genre_scores_gemma":[0.5078565,0.002829445,0.0001784689,0.08227412,0.003624139,0.001132478,0.00736003,0.0009426167,0.3938021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3459222,"threshold_uncertainty_score":0.9996389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029866241166117,"score_gpt":0.2597014960927492,"score_spread":0.239402833681088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}