{"id":"W3112505324","doi":"10.1093/neuonc/noaa222.427","title":"LGG-49. SAFETY AND EFFICACY OF TRAMETINIB (T) MONOTHERAPY AND DABRAFENIB + TRAMETINIB (D+T) COMBINATION THERAPY IN PEDIATRIC PATIENTS WITH <i>BRAF</i> V600-MUTANT LOW-GRADE GLIOMA (LGG)","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Trametinib; Combination therapy; Dabrafenib; Internal medicine; Adverse effect; Interim analysis; Refractory (planetary science); Oncology; Phases of clinical research; Clinical trial; Gastroenterology; Cancer; MAPK/ERK pathway; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005943323,0.0003572287,0.0007498437,0.0002506542,0.0001738036,0.0004858115,0.0003408419,0.0003431156,0.001655916],"category_scores_gemma":[0.0005606135,0.0001927905,0.0005895678,0.0003519752,0.0003666743,0.0003021709,0.0002003263,0.0008273314,0.0004173072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008607293,"about_ca_system_score_gemma":0.001135327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001791063,"about_ca_topic_score_gemma":0.005157913,"domain_scores_codex":[0.9996526,0.0001585848,0.00002066266,0.00005634172,0.00005070898,0.00006106651],"domain_scores_gemma":[0.9996939,0.00004740692,0.00008674049,0.0000242056,0.00002292025,0.0001248477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3297661,0.01528938,0.2045995,0.001387793,0.002478226,0.001704594,0.0004652537,0.00597378,0.1008962,0.0004674651,0.01476829,0.3222035],"study_design_scores_gemma":[0.1157471,0.4288127,0.3938385,0.0001986337,0.002562577,0.003591955,0.0003269356,0.005160647,0.03068264,0.0003483927,0.01866535,0.00006471221],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948648,0.001860879,0.0001628932,0.000154525,0.00001832617,0.0002640045,0.00127823,0.00005594518,0.001340471],"genre_scores_gemma":[0.9964953,0.0006321225,0.0004537156,0.0001953916,0.00001742197,0.0001913857,0.001702675,0.0000111506,0.0003007775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791063,"threshold_uncertainty_score":0.006245077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461166321155576,"score_gpt":0.2631272452615063,"score_spread":0.2485155820499505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}