{"id":"W3112507268","doi":"10.1016/j.jval.2020.08.1234","title":"PMU22 Cost of Inotersen and Patisiran for the Treatment of Adults with Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis in Canada, Germany, and Italy","year":2020,"lang":"en","type":"article","venue":"Value in Health","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Transthyretin; Polyneuropathy; Amyloidosis; Medicine; Amyloid polyneuropathy; Pediatrics; Internal medicine; Disease; Age of onset","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002400892,0.0002573421,0.000353625,0.0004624539,0.0003686009,0.0005114278,0.0003133322,0.0005017347,0.006160808],"category_scores_gemma":[0.0009093517,0.0001140112,0.0005161279,0.0006439065,0.0003614046,0.000164773,0.0004212595,0.000787371,0.0006005533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003994207,"about_ca_system_score_gemma":0.005069509,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.09837044,"about_ca_topic_score_gemma":0.1502615,"domain_scores_codex":[0.9996617,0.00007351168,0.00002009009,0.00003285085,0.00008388278,0.0001278774],"domain_scores_gemma":[0.999199,0.00005863856,0.00008261818,0.00001567842,0.00005411339,0.0005899879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.04383677,0.00362712,0.2554217,0.001067079,0.00159264,0.004976107,0.000243163,0.003437645,0.005316852,0.003147864,0.1321759,0.5451573],"study_design_scores_gemma":[0.008547808,0.006975546,0.9003995,0.0006621414,0.0008860389,0.004568741,0.000270397,0.002073481,0.0007293349,0.0004690193,0.07435592,0.00006201901],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9037864,0.02655989,0.0003311046,0.01685082,0.0006664518,0.0003964566,0.008631155,0.0001668266,0.042611],"genre_scores_gemma":[0.9774852,0.007154367,0.0005466734,0.00278115,0.0005953345,0.0001751369,0.003800373,0.00002808924,0.007433641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9016296,"threshold_uncertainty_score":0.1955957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531075637710905,"score_gpt":0.2310184123288709,"score_spread":0.2157076559517618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}