{"id":"W3112509373","doi":"10.7150/jca.50376","title":"GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer","year":2020,"lang":"en","type":"review","venue":"Journal of Cancer","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; HIV Legal Network; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Cachexia; GDF15; Medicine; Cancer; Inflammation; Glial cell line-derived neurotrophic factor; Neurotrophic factors; Bioinformatics; Anorexia; Energy homeostasis; Immunology; Internal medicine; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841576,0.0004214814,0.002486954,0.0003196133,0.00003130662,0.00001873549,0.0001824186,0.0004733768,0.0002913375],"category_scores_gemma":[0.00007121275,0.000225958,0.0007516239,0.0005512506,0.00005174893,0.00008423645,0.0000231137,0.001357377,0.00000517141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004159248,"about_ca_system_score_gemma":0.003286816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008933525,"about_ca_topic_score_gemma":0.00008655876,"domain_scores_codex":[0.9978899,0.0000712341,0.0008735881,0.0002650542,0.0005686571,0.0003315657],"domain_scores_gemma":[0.997932,0.0000601187,0.001158014,0.000150794,0.0004027667,0.0002963684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001276436,0.0001418235,0.001635056,0.006431599,0.002732414,0.0002110169,0.00009902693,0.000006043165,0.000002025766,0.000006996623,0.006200673,0.9812569],"study_design_scores_gemma":[0.004285053,0.0006542632,0.001063699,0.02672093,0.004493293,0.00006169619,0.00001377818,0.000001418227,0.000007546643,0.00000591959,0.9624352,0.0002571914],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006324865,0.9963465,0.000003196687,0.0005095582,0.0009897923,0.001145616,0.0001616726,0.000007304472,0.0002038815],"genre_scores_gemma":[0.0002411456,0.9970743,0.0001383132,0.0004502906,0.0009615402,0.00009911766,0.00003824448,0.00008810196,0.0009089133],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9809997,"threshold_uncertainty_score":0.9214301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710207082634004,"score_gpt":0.3371119847231574,"score_spread":0.3200099138968174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}