{"id":"W3112509373","doi":"10.7150/jca.50376","title":"GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer","year":2020,"lang":"en","type":"review","venue":"Journal of Cancer","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; HIV Legal Network; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Cachexia; GDF15; Medicine; Cancer; Inflammation; Glial cell line-derived neurotrophic factor; Neurotrophic factors; Bioinformatics; Anorexia; Energy homeostasis; Immunology; Internal medicine; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004594846,0.0006153343,0.0012036,0.001182421,0.0001489596,0.0006580891,0.0004611276,0.0007735574,0.00178334],"category_scores_gemma":[0.0007679983,0.0001792883,0.0008061616,0.0008744536,0.0002347913,0.0005134372,0.0004037822,0.001258728,0.0006149784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005111453,"about_ca_system_score_gemma":0.0009188329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303937,"about_ca_topic_score_gemma":0.002949647,"domain_scores_codex":[0.9998811,0.00002976319,0.0000208717,0.00002037579,0.00003442123,0.00001338266],"domain_scores_gemma":[0.9997891,0.0001012439,0.00003333143,0.000004302317,0.00005657778,0.00001542848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000290145,0.00005703472,0.001182036,0.02020662,0.000478313,0.0002108936,0.00006263573,0.0003106908,0.001278942,0.002092389,0.02065106,0.9531793],"study_design_scores_gemma":[0.0001317582,0.0004411519,0.008571549,0.01238164,0.001528241,0.003080167,0.0001399483,0.0003952718,0.001419235,0.002541334,0.9693069,0.00006281707],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002128254,0.9991009,0.00005258989,0.0002164618,0.00009512134,0.000004181146,0.00001972181,0.000003555864,0.0002947066],"genre_scores_gemma":[0.00186299,0.9972479,0.0001626427,0.0002340183,0.00009826626,0.000009587689,0.00005588965,0.000001133064,0.0003275361],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00178334,"threshold_uncertainty_score":0.005965889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710207082634004,"score_gpt":0.3371119847231574,"score_spread":0.3200099138968174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}