{"id":"W3112527772","doi":"10.3390/cells9122702","title":"Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Faculty of Dentistry, University of Toronto; University of Toronto; Deutsche Forschungsgemeinschaft; E-Rare; Heart and Stroke Foundation of Canada","keywords":"Myofibroblast; Cell biology; Cardiac fibrosis; Fibroblast; Mechanotransduction; Gene knockdown; Myocardin; Focal adhesion; Fibrosis; Actin; Downregulation and upregulation; Transcription factor; Chemistry; Biology; Signal transduction; Cell culture; Serum response factor; Medicine; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004750974,0.00007653442,0.0001075153,0.00001385718,0.00002102734,0.000006903962,0.00009330126,0.00008962988,0.00008984159],"category_scores_gemma":[0.00004917576,0.00007567109,0.0001039024,0.0000595885,0.00001291443,0.000002797677,0.0000668646,0.00006061357,0.00003172026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004275496,"about_ca_system_score_gemma":0.00002800537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005092452,"about_ca_topic_score_gemma":5.932677e-7,"domain_scores_codex":[0.9994695,0.00002592643,0.0001423376,0.0001811822,0.00008311629,0.0000979692],"domain_scores_gemma":[0.9996504,0.00001145673,0.00006488011,0.0001417443,0.00005653839,0.0000750124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000265485,0.0000211815,0.000008351601,0.00001205642,0.0000287409,1.627219e-7,0.00002992218,0.00002148833,0.9956173,0.0002333717,0.003255039,0.0007458163],"study_design_scores_gemma":[0.0000896958,0.0001780393,0.00001657339,0.000005768314,0.00001031764,2.479665e-7,0.00004317033,0.0003658454,0.9283516,0.0000426334,0.0708234,0.00007268101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873655,0.0002105605,0.009254919,0.0006166938,0.0004841622,0.0001922462,0.00004278729,0.00001636702,0.001816721],"genre_scores_gemma":[0.9986658,0.0001187977,0.000475972,0.0002309123,0.000263115,0.000004635772,0.00009295584,0.00001371376,0.000134107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06756836,"threshold_uncertainty_score":0.3085777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085715449171931,"score_gpt":0.2226581289654989,"score_spread":0.2118009744737796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}