{"id":"W3112527772","doi":"10.3390/cells9122702","title":"Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Faculty of Dentistry, University of Toronto; University of Toronto; Deutsche Forschungsgemeinschaft; E-Rare; Heart and Stroke Foundation of Canada","keywords":"Myofibroblast; Cell biology; Cardiac fibrosis; Fibroblast; Mechanotransduction; Gene knockdown; Myocardin; Focal adhesion; Fibrosis; Actin; Downregulation and upregulation; Transcription factor; Chemistry; Biology; Signal transduction; Cell culture; Serum response factor; Medicine; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386515,0.0004135482,0.000175757,0.0001747273,0.0001871047,0.0001795436,0.0001537369,0.0002256238,0.0009100391],"category_scores_gemma":[0.0001042216,0.0001409751,0.0001840146,0.00009399734,0.0001526058,0.0002304843,0.0002365529,0.0002602874,0.0002573205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002674056,"about_ca_system_score_gemma":0.0001091709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002295498,"about_ca_topic_score_gemma":0.0004998994,"domain_scores_codex":[0.9998741,0.0000234157,0.00001133783,0.00002645231,0.00003291673,0.00003172117],"domain_scores_gemma":[0.9999378,0.00001022809,0.00001807305,0.000007606467,0.000006951879,0.00001938819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002652767,0.00000417911,0.00005312488,0.00001831332,0.000001757162,0.00003725492,0.000004592231,0.00001428897,0.9995508,0.00004193096,0.00001567839,0.0002314843],"study_design_scores_gemma":[0.00001613938,0.00009042557,0.00345692,0.000002946255,0.000008092245,0.0004135052,0.00001439582,0.0004597645,0.9936661,0.00006143883,0.00180748,0.000002836076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930975,0.00251738,0.002582429,0.0001310039,0.00003083374,0.00002184193,0.0001797523,0.00005229783,0.00138705],"genre_scores_gemma":[0.9942404,0.001172251,0.001936994,0.00007243779,0.0000194718,0.00004260815,0.0003846276,0.00001393467,0.002117298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009100391,"threshold_uncertainty_score":0.003044426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085715449171931,"score_gpt":0.2226581289654989,"score_spread":0.2118009744737796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}