{"id":"W3112536513","doi":"10.3390/pharmaceutics12121217","title":"In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Instituto de Salud Carlos III; Natural Sciences and Engineering Research Council of Canada; Servier; Centres de Recerca de Catalunya; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; Fonds de recherche du Québec – Nature et technologies; Université de Montréal; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria","keywords":"Antimicrobial; Chemistry; Escherichia coli; Peptide; Green fluorescent protein; In vivo; Inclusion bodies; In vitro; Antibiotics; Recombinant DNA; Antimicrobial peptides; Microbiology; Biochemistry; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667949,0.0003325393,0.0001815427,0.0001371374,0.00005847025,0.0001241878,0.000119242,0.0003377253,0.0004854292],"category_scores_gemma":[0.00009928841,0.00009349905,0.0001294726,0.00005866037,0.0001441104,0.0001509137,0.00008691911,0.0003512949,0.0001026823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000105454,"about_ca_system_score_gemma":0.00008997503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002074384,"about_ca_topic_score_gemma":0.0002146885,"domain_scores_codex":[0.999916,0.00002148667,0.000005295378,0.00001834239,0.0000167734,0.00002219169],"domain_scores_gemma":[0.9999443,0.00001573906,0.00001474946,0.000006078526,0.000007392942,0.00001163287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000119431,0.00003837922,0.00003441308,0.00001689286,0.000001815241,0.00001168638,0.00000530332,0.00005269579,0.9992175,0.00001781023,0.000009133911,0.0004748831],"study_design_scores_gemma":[0.00001239006,0.000839796,0.0006914736,0.000002031997,0.000007039134,0.00003715337,0.000005787992,0.0006090642,0.9975271,0.00001000102,0.0002565052,0.000001659547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981109,0.0005347158,0.000927397,0.00002518743,0.00001627967,0.00001293738,0.00005616177,0.00001780147,0.0002986565],"genre_scores_gemma":[0.9972254,0.0004029782,0.001256534,0.00002405948,0.000007674184,0.00002152512,0.0001087452,0.000006519148,0.0009465371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004854292,"threshold_uncertainty_score":0.001623869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284618334603541,"score_gpt":0.2890915041340517,"score_spread":0.2606296706736976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}