{"id":"W3112536513","doi":"10.3390/pharmaceutics12121217","title":"In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics","year":2020,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Instituto de Salud Carlos III; Natural Sciences and Engineering Research Council of Canada; Servier; Centres de Recerca de Catalunya; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; Fonds de recherche du Québec – Nature et technologies; Université de Montréal; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria","keywords":"Antimicrobial; Chemistry; Escherichia coli; Peptide; Green fluorescent protein; In vivo; Inclusion bodies; In vitro; Antibiotics; Recombinant DNA; Antimicrobial peptides; Microbiology; Biochemistry; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001133418,0.0002712619,0.0004306658,0.0001109131,0.00008320762,0.00002314642,0.0003028325,0.0001229157,0.0003408688],"category_scores_gemma":[0.00007658305,0.0002629222,0.000121922,0.0002694294,0.0001923491,0.0001280399,0.0001906558,0.0003866001,0.0002570892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004139819,"about_ca_system_score_gemma":0.00005379453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009300127,"about_ca_topic_score_gemma":0.000008099957,"domain_scores_codex":[0.9984522,0.0001554172,0.0004503749,0.0003852856,0.00006592149,0.0004907607],"domain_scores_gemma":[0.9994614,0.00006969053,0.0001677057,0.0001658873,0.00005624296,0.00007906004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001947146,0.0004977203,0.0003482531,0.00006464429,0.0001087964,0.00004454394,0.001169373,0.001076572,0.9896631,0.00019467,0.00452388,0.000361356],"study_design_scores_gemma":[0.002709859,0.0004062675,0.0004353657,0.000103421,0.00004756055,0.00001427088,0.000106929,0.0001817988,0.9875657,0.000008677001,0.008140834,0.000279332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957208,0.00003405424,0.0002327899,0.002433238,0.0004220678,0.000647752,0.000253641,0.00004332139,0.0002123159],"genre_scores_gemma":[0.9963304,0.00002249964,0.0003723395,0.002689509,0.0001247837,0.000002029612,0.00001979161,0.00003433859,0.0004043266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003616954,"threshold_uncertainty_score":0.9999823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284618334603541,"score_gpt":0.2890915041340517,"score_spread":0.2606296706736976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}