{"id":"W3112571488","doi":"10.1002/rth2.12459","title":"Complement factor C4a does not activate protease‐activated receptor 1 (PAR1) or PAR4 on human platelets","year":2020,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Center for AIDS Research, University of Washington; Danone Institute of Canada; National Institutes of Health; Case Western Reserve University; American Association of Heart Failure Nurses; American Heart Association","keywords":"C4A; Thrombin; Protease-activated receptor; Cell biology; Platelet; Platelet activation; Proteases; Receptor; Complement system; HEK 293 cells; Chemistry; Biology; Immunology; Biochemistry; Enzyme; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002313026,0.0002359974,0.0001967975,0.0002061391,0.0002747804,0.0004123299,0.0003084951,0.0003808146,0.004962012],"category_scores_gemma":[0.000486653,0.0001111352,0.0003222322,0.0002537832,0.0001946781,0.0001749751,0.0002175816,0.0003422957,0.0006214461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004637073,"about_ca_system_score_gemma":0.0003342821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002983778,"about_ca_topic_score_gemma":0.001738461,"domain_scores_codex":[0.9994439,0.0001066454,0.00003520991,0.0001022306,0.0001764369,0.0001354891],"domain_scores_gemma":[0.999844,0.00005211258,0.00002916123,0.00002847131,0.00003306679,0.00001322052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003788615,0.00003912916,0.001278849,0.0001519202,0.00003671959,0.0002457705,0.00004702131,0.0001437656,0.9924536,0.0003494762,0.000456711,0.00441823],"study_design_scores_gemma":[0.00005678116,0.0007022014,0.02305544,0.00003276053,0.00008928434,0.001696226,0.00008363357,0.001821632,0.9604051,0.0002017907,0.01184005,0.00001514272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855359,0.004384125,0.003607163,0.0002873791,0.00005006345,0.0001120575,0.001085796,0.00005113267,0.004886399],"genre_scores_gemma":[0.9931912,0.0008761658,0.001571378,0.0001436379,0.0000226602,0.00008669071,0.001138894,0.00001118057,0.002958324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004962012,"threshold_uncertainty_score":0.01659954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4595018656371428,"score_gpt":0.4899120314925583,"score_spread":0.03041016585541545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}