{"id":"W3112590295","doi":"10.1126/science.abc8059","title":"Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute on Aging; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Donald E. and Delia B. Baxter Foundation; Canadian Institutes of Health Research; Li Ka Shing Foundation; California Institute for Regenerative Medicine","keywords":"Enzyme; Chemistry; Prostaglandin; Muscle mass; Biochemistry; Biology; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173967,0.00006359573,0.00007766843,0.0000357091,0.00008778655,0.00002440496,0.00008781184,0.00003609195,0.000007701879],"category_scores_gemma":[0.0001332658,0.00005767755,0.00002063132,0.0002132035,0.0002259905,0.00001330112,0.00005923872,0.00004127245,0.000001012013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003377531,"about_ca_system_score_gemma":0.0000350491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000420662,"about_ca_topic_score_gemma":0.000002355899,"domain_scores_codex":[0.9993315,0.00002130733,0.0001099054,0.0002610405,0.000138598,0.0001376454],"domain_scores_gemma":[0.9997054,0.000005483465,0.00005531916,0.0001034004,0.00004536405,0.00008503398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001658169,0.0000110137,0.0011444,0.0000239524,0.000001259922,7.426863e-7,0.000112094,0.000002161451,0.9966992,0.00007354405,0.0001264523,0.001788638],"study_design_scores_gemma":[0.0003805482,0.0001304332,0.01513092,0.00001621598,0.000004488102,0.000001240626,0.0001100248,0.0001567506,0.9816155,0.0001890427,0.002185377,0.00007939406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981746,0.0006665732,0.0005332843,0.0002395279,0.00005332017,0.00009660415,0.00002197442,0.000008164135,0.0002059464],"genre_scores_gemma":[0.9985747,0.0001772444,0.0009731311,0.0001488397,0.00008003277,0.000004081076,0.00002117198,0.000004474005,0.00001627675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01508359,"threshold_uncertainty_score":0.2352022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266547076240568,"score_gpt":0.2330957772894128,"score_spread":0.2204303065270072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}