{"id":"W3112630471","doi":"10.3389/fimmu.2020.612402","title":"Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"UK Dementia Research Institute; Life Sciences Research Network Wales; Cardiff University; Health and Care Research Wales; International Seafood Sustainability Foundation; Wellcome Trust","keywords":"Monoclonal antibody; Eculizumab; Anaphylatoxin; Complement system; Complement component 5; Paroxysmal nocturnal hemoglobinuria; Atypical hemolytic uremic syndrome; Lytic cycle; CD59; Pharmacology; Complement membrane attack complex; Antibody; Monoclonal; Properdin; Immunology; Medicine; Chemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958085,0.0001996011,0.0007954115,0.0003369726,0.0000469683,0.000003344527,0.0003590025,0.0001375735,0.0004713181],"category_scores_gemma":[0.0002626563,0.0002088668,0.0001058362,0.0002937081,0.0005489385,0.00007434225,0.0002754989,0.0002284475,0.00001781355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007862459,"about_ca_system_score_gemma":0.00007335034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006355096,"about_ca_topic_score_gemma":0.00020138,"domain_scores_codex":[0.9979554,0.000288558,0.0009562061,0.0003188007,0.00005154409,0.0004294232],"domain_scores_gemma":[0.9991432,0.0001913593,0.000349453,0.0002373279,0.00006300013,0.0000156339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003890112,0.0002000722,0.692957,0.000117589,0.000196536,0.000006943309,0.001652133,0.0001017082,0.2977104,0.0005544453,0.005359358,0.0007548156],"study_design_scores_gemma":[0.008357619,0.0006407031,0.530687,0.0004346422,0.00005149279,0.00001427217,0.0235001,0.0002214712,0.4229635,0.0004288247,0.01224139,0.0004589641],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885285,0.008562041,0.0003931962,0.0003103339,0.0007912184,0.0004284374,0.0002279876,0.00002712394,0.0007311332],"genre_scores_gemma":[0.997785,0.0001474326,0.001728927,0.00004059735,0.00001600715,0.00002815692,0.0001683757,0.00001340201,0.00007214066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.16227,"threshold_uncertainty_score":0.8517339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862348583931208,"score_gpt":0.2358020449447541,"score_spread":0.2071785591054421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}