{"id":"W3112630471","doi":"10.3389/fimmu.2020.612402","title":"Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"UK Dementia Research Institute; Life Sciences Research Network Wales; Cardiff University; Health and Care Research Wales; International Seafood Sustainability Foundation; Wellcome Trust","keywords":"Monoclonal antibody; Eculizumab; Anaphylatoxin; Complement system; Complement component 5; Paroxysmal nocturnal hemoglobinuria; Atypical hemolytic uremic syndrome; Lytic cycle; CD59; Pharmacology; Complement membrane attack complex; Antibody; Monoclonal; Properdin; Immunology; Medicine; Chemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002680189,0.0008828103,0.0003399194,0.0004400084,0.0001631847,0.0002933197,0.0004996234,0.0006353729,0.00198767],"category_scores_gemma":[0.0001746136,0.0002432514,0.0003818839,0.0002222351,0.0001816033,0.0002547003,0.0002559281,0.0008762639,0.0007011554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007273229,"about_ca_system_score_gemma":0.0003525366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008838632,"about_ca_topic_score_gemma":0.001600517,"domain_scores_codex":[0.9997186,0.00003219395,0.00002270833,0.00005431499,0.00008579847,0.00008635298],"domain_scores_gemma":[0.9999034,0.00001958887,0.0000224022,0.00001540666,0.000023612,0.00001553561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001207566,0.0001207469,0.000140029,0.00008078208,0.00001986722,0.00005607802,0.00001103113,0.0001731691,0.9901274,0.0003995281,0.0003398989,0.008410694],"study_design_scores_gemma":[0.0001197033,0.001521013,0.002015468,0.00002791722,0.00009853261,0.0005225408,0.000008559294,0.001364988,0.9784448,0.0001383663,0.01572528,0.00001291144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924027,0.02369343,0.02813324,0.0009226817,0.0003594868,0.0005998221,0.0009686456,0.0006350992,0.02066054],"genre_scores_gemma":[0.954073,0.009248046,0.0237813,0.0007044697,0.000108949,0.0004851536,0.001204309,0.00003715232,0.01035767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00198767,"threshold_uncertainty_score":0.006649435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862348583931208,"score_gpt":0.2358020449447541,"score_spread":0.2071785591054421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}