{"id":"W3112653889","doi":"10.1093/neuonc/noaa222.598","title":"MODL-25. REPLICATION REPAIR DEFICIENT MOUSE MODELS PROVIDE INSIGHT ON HYPERMUTANT BRAIN TUMOURS, MECHANISMS OF IMMUNE EVASION, AND COMBINATORIAL IMMUNOTHERAPY","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Immunoediting; Cancer research; Biology; Nestin; OLIG2; Immune system; Immunotherapy; Conditional gene knockout; Medulloblastoma; Immunology; Gene; Central nervous system; Oligodendrocyte; Phenotype; Stem cell; Neuroscience; Neural stem cell; Myelin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004056376,0.0009276779,0.0004131056,0.001809031,0.000392998,0.0007202259,0.0006530462,0.0009374977,0.005112041],"category_scores_gemma":[0.0001182416,0.0004245178,0.0004852063,0.0003721804,0.0006157837,0.0007648621,0.0004121959,0.001781113,0.001676819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007707873,"about_ca_system_score_gemma":0.0003967155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005320086,"about_ca_topic_score_gemma":0.001631717,"domain_scores_codex":[0.9996692,0.00004281911,0.00003318095,0.00007422196,0.00009222776,0.00008842752],"domain_scores_gemma":[0.999689,0.00002375325,0.0001262972,0.00002997068,0.0000167351,0.0001142824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000446393,0.0002231562,0.0006506867,0.0001346389,0.00002327064,0.0004070036,0.00005222325,0.0003220527,0.9893643,0.002451944,0.001030779,0.004893548],"study_design_scores_gemma":[0.0002021464,0.001454334,0.006051473,0.0001027272,0.00008635446,0.002396459,0.0001294676,0.003067413,0.9477782,0.001203057,0.03749918,0.00002910942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482542,0.005256997,0.02094128,0.001779024,0.0002386048,0.0003099045,0.009225639,0.001970561,0.01202377],"genre_scores_gemma":[0.9363927,0.003463262,0.01860308,0.000577539,0.0000738429,0.0005723488,0.005516109,0.0004421866,0.03435883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005112041,"threshold_uncertainty_score":0.01710153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110315241964064,"score_gpt":0.2650256486959736,"score_spread":0.2439224962763329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}