{"id":"W3112670293","doi":"10.1093/neuonc/noaa215.191","title":"CTNI-24. A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY. TRAM-01","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Dalhousie University; University of Toronto; University of British Columbia; Hospital for Sick Children; McGill University Health Centre; Centre hospitalier universitaire de Québec; Université du Québec à Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Trametinib; Tolerability; Internal medicine; Adverse effect; MAPK/ERK pathway; Progressive disease; Oncology; Gastroenterology; Progression-free survival; Surgery; Disease; Overall survival; Kinase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001566026,0.001810454,0.001469858,0.0004902177,0.0003819404,0.0008463548,0.001217371,0.00112754,0.003761341],"category_scores_gemma":[0.0007257488,0.0006560726,0.001073597,0.0005534004,0.0007283405,0.0006542812,0.0002829029,0.002881095,0.001111392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001397654,"about_ca_system_score_gemma":0.002307311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002389048,"about_ca_topic_score_gemma":0.007146351,"domain_scores_codex":[0.9996208,0.0001888168,0.00001506805,0.00004905038,0.00003513385,0.00009111445],"domain_scores_gemma":[0.9994544,0.00005479316,0.0001059036,0.00003127121,0.0000366093,0.0003169747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5645112,0.1076089,0.01419799,0.002271296,0.001986686,0.001460342,0.0005761979,0.006328975,0.09249189,0.0008296426,0.01418898,0.193548],"study_design_scores_gemma":[0.5373896,0.426541,0.0177641,0.000076484,0.0005605711,0.00136889,0.00009686165,0.001979497,0.00707472,0.0001574573,0.006941407,0.00004940519],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843699,0.004307262,0.0006188005,0.000666817,0.0001593568,0.004411027,0.002563129,0.0001796921,0.002724104],"genre_scores_gemma":[0.975634,0.004957872,0.002952208,0.0009599316,0.0001887847,0.005169692,0.005660905,0.00006165358,0.004414906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003761341,"threshold_uncertainty_score":0.01258296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.026646744472563,"score_gpt":0.2899561925069944,"score_spread":0.2633094480344314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}