{"id":"W3112674796","doi":"10.1002/alz.045461","title":"Rationally designed antibodies selective for pathogenic tau aggregates","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada); University of British Columbia","funders":"","keywords":"Epitope; Thioflavin; Monoclonal antibody; Tau protein; Chemistry; Förster resonance energy transfer; Antibody; Peptide; Protein aggregation; Biochemistry; Biophysics; Molecular biology; Alzheimer's disease; Fluorescence; Biology; Immunology; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004413232,0.000751778,0.0003907348,0.0003076454,0.0001993627,0.0005662363,0.0005969708,0.0006150775,0.001403579],"category_scores_gemma":[0.0004922501,0.0003399208,0.0003129006,0.0002139175,0.0002341193,0.0003173944,0.0002918463,0.000836779,0.0006800435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008248393,"about_ca_system_score_gemma":0.0003974783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006057163,"about_ca_topic_score_gemma":0.001244559,"domain_scores_codex":[0.9996995,0.00005408945,0.00002063728,0.00006319303,0.00008165597,0.00008096815],"domain_scores_gemma":[0.9998288,0.00004224748,0.00003523412,0.00001454443,0.00005136174,0.00002767652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000266532,0.0003498716,0.0007281831,0.0001539676,0.00003838736,0.0002030176,0.00002931758,0.01254838,0.9719393,0.002684447,0.0008492536,0.01020935],"study_design_scores_gemma":[0.0002243239,0.0008961641,0.00046208,0.00002123006,0.00006561959,0.0002570373,0.00002290516,0.03236439,0.9554647,0.0005551148,0.009644205,0.00002238611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8761641,0.003597782,0.1057515,0.0006378597,0.0003492118,0.0006652171,0.0005423217,0.0006051928,0.01168688],"genre_scores_gemma":[0.9493541,0.001169718,0.04507294,0.0004734231,0.00002409149,0.0002683614,0.0004380678,0.00005446323,0.00314471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001403579,"threshold_uncertainty_score":0.005984664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04502227526653947,"score_gpt":0.3141047387498768,"score_spread":0.2690824634833373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}